Indications 

Zovirax Ophthalmic Ointment is a medication used to treat herpes simplex virus infections of the cornea of the eye. It can be used to treat acute herpetic keratitis (dendritic ulcers) in patients with herpes simplex virus (HSV-1 and HSV-2). Note that Zovirax Ophthalmic Ointment is specifically formulated for use in the eye and should not be used on other parts of the body. 

The Ointment contains the active ingredient acyclovir, which belongs to a group of medicines called antivirals. It works by inhibiting the replication of the herpes simplex virus (HSV) responsible for the infection. Acyclovir, the active ingredient, is converted into its active form inside infected cells. It then interferes with viral DNA synthesis, preventing the virus from multiplying and spreading further. By blocking viral replication, Acyclovir helps reduce the infection’s duration and severity, and alleviates symptoms such as pain, redness, and swelling. 

Use and Dosage 

The dosage and frequency of application may vary depending on the severity of the infection and your healthcare professional’s instructions. Typically, a small amount of ointment (about 1cm) is applied to the affected eye(s) five times a day, every four hours during the day (but not during the night). Follow the prescribed dosage and schedule. 

Before applying the ointment, make sure to wash your hands thoroughly to prevent the spread of infection. Gently clean the affected eye(s) with sterile saline or water to remove any discharge or debris. Avoid touching or rubbing the eye(s) while doing so. Using a clean finger or a sterile cotton swab, pull down the lower eyelid to create a small pocket. Apply a thin strip of ointment into the pocket, being careful not to touch the eye with the tip of the tube or your finger. Close the eye gently for a few moments to allow the ointment to spread evenly over the eye surface.  

If you wear contact lenses, remove them before applying the ointment and wait at least 15 minutes before reinserting them. Zovirax Ophthalmic Ointment may contain ingredients that can discolor or damage contact lenses. 

Side Effects 

Common Side Effects

• Eye pain or sting 
• Painful irritation of the clear front part of the eye 
• Redness, itching, pain, swelling, or other irritation of the eye 

Serious Side Effects 

• Hives, itching, rash, swelling of the eyes, face, lips, mouth, throat, or tongue 
• New or worsening red, watery eyes, eye sensitivity to light, blurred vision, or pain around the eye 

Cautions 

• Allergic reactions: If you are allergic to acyclovir or any other ingredients in the ointment, you should avoid using it. Inform your doctor about any known allergies before starting treatment.  
• Pre-existing eye conditions: If you have any pre-existing eye conditions, inform your doctor before using Zovirax Ophthalmic Ointment. They will assess whether it is suitable for you and may provide specific instructions or precautions.  
• Contact lenses: Zovirax Ophthalmic Ointment may contain ingredients that can discolor or damage contact lenses. If you wear contact lenses, remove them before applying the ointment and wait at least 15 minutes before reinserting them.  
• Systemic absorption: Although Acyclovir is primarily used on the eye, there is a possibility of systemic absorption (absorption into the bloodstream). If you experience any unusual or systemic side effects, such as extreme tiredness, swelling, or changes in urination, seek medical attention.  
• Eye irritation: Acyclovir may cause temporary eye irritation, such as stinging or burning sensations. If you experience persistent or worsening irritation, redness, or discomfort, contact your healthcare professional. 
• Infection spread: To prevent the spread of infection, avoid touching or rubbing your eyes unnecessarily, especially when applying the ointment. Wash your hands before and after applying the ointment to minimize the risk of contamination.  
• Avoid sharing: Do not share the ointment with others, even if they have similar symptoms. Sharing medication can lead to the spread of infection or other complications. 
• Safety in children: The safety and efficacy of Acyclovir in children have not been fully established. If you are considering using the medication for a child, consult with a pediatrician for appropriate guidance and dosage instructions.  
• Drug interactions: Inform your healthcare professional about all the medications, supplements, or eye drops you are currently using, as there is a possibility of drug interactions. They can assess potential interactions and provide guidance on the safe use of Acyclovir.