Indications 

Xerese is a topical medication prescribed for the early treatment of recurrent herpes labialis (cold sores) in adults and children (6 years and older) to minimize the chances of ulcerative cold sores and expedite lesion healing. 

Xerese contains two medications: acyclovir, an antiviral agent, and hydrocortisone, a corticosteroid. 

Acyclovir works by inhibiting the growth and spread of the herpes virus, enabling the body to combat the infection. On the other hand, hydrocortisone works by diminishing the effects of inflammation-causing chemicals in the body. 

Uses and Dosage 

Before using Xerese and with every prescription refill, carefully review the medication guide and patient information leaflet given by your pharmacist. Consult your doctor or pharmacist if you have any inquiries or concerns. 

Xerese is meant for external use only on cold sores around the lips and mouth.  It should not be applied to the eyes, inside the mouth or nose, or on the genital area. 

Typically, this cream is administered at the first sign of a cold sore, with a recommended frequency of application of 5 times daily (every 3 to 4 hours) for 5 days. 

To properly use Xerese, follow these steps: 

1. Wash your hands with soap and water before applying the cream. 
2. Clean and dry the affected area. 
3. Apply a thin layer of the cream to the affected area, including the outer edge of the cold sore. 
   • Avoid rubbing the affected area to prevent spreading or worsening the cold sore. 
   • Do not use other skin products like makeup, sunscreen, or lip balm, and refrain from covering the treated area with a bandage. 
   • Wait for 30 minutes after applying the cream before bathing, showering, or swimming to prevent washing off the medication. 
4. Remember to wash your hands after each application. 

Follow the complete prescribed course of Xerese, even if your symptoms improve rapidly. Contact your doctor if there is no improvement after two weeks. 

Side Effects 

Listed below are the potential adverse effects of Xerese. Notify your doctor immediately if any of these symptoms endure or worsen. 

Common Side Effects 

• Mild burning or tingling sensation following application 
• Skin dryness or flaking 
• Swelling 
• Skin redness or discoloration 

Serious Side Effects 

• Severe burning, stinging, or irritation of the treated area 

Stop using Xerese and call your doctor at once if you experience the severe symptoms above. 

Allergic Reactions 

In rare cases, Xerese may trigger a serious allergic response. Seek immediate medical help if you observe any indications of an allergic reaction, such as: 

• Hives 
• Face, lips, tongue, or throat swelling 
• Trouble breathing 

This list does not encompass all potential side effects of Xerese. Tell your doctor if you encounter any unlisted side effects. 

Cautions 

Before starting treatment with Xerese, inform your doctor if you have any known allergies, particularly to acyclovir or hydrocortisone. 

Ask for more details about this cream from your pharmacist, as it may contain inactive components that could trigger allergic reactions or other complications. 

Disclose your medical background with your doctor to ascertain the suitability of Xerese for your use. 

Xerese is considered to have a low likelihood of interacting with other medications. However, informing all your healthcare providers about your complete medication regimen is recommended, which includes prescription and over-the-counter drugs, as well as vitamins and herbal products. 

The use of Xerese does not provide protection against the transmission of genital herpes. To prevent the virus from spreading to others: 

• Abstain from sexual activity or use latex condoms 

• Keep infected areas away from others 
• Refrain from touching the affected area and then your eyes 
• Practicing regular hand hygiene 

Prior to using Xerese, inform your doctor about your pregnancy status, as its impact on the unborn baby is not known. 

If you are breastfeeding, discuss with your doctor the most suitable feeding method for your baby when using Xerese, as it is uncertain whether acyclovir or hydrocortisone transfers to breast milk.