Indications 

Xeloda is an antineoplastic agent that functions by impeding the proliferation of malignant cells and impeding their dissemination throughout the body.  

This medication is administered either as a monotherapy or in conjunction with other chemotherapeutic agents to manage colon cancer, breast cancer, or colorectal cancer.  

In certain cases, Xeloda is utilized as a treatment option when cancer has advanced to distant sites in the body, a condition commonly known as metastatic cancer. 

Uses and Dosage 

Prior to initiating treatment with capecitabine, kindly peruse the Patient Information Leaflet, if made available by your pharmacist, and repeat the same process each time you refill your prescription. In case of any inquiries, kindly seek clarification from your physician or pharmacist. 

Take this medication orally as directed by your physician, generally twice daily at 12-hour intervals. Your doctor may recommend taking this medication in a specific treatment cycle. Adhere to your physician’s instructions. 

Swallow the tablets whole with water within half an hour after eating. Refrain from crushing, chewing, or splitting the tablets. In case you encounter difficulties swallowing the tablets, consult your healthcare provider for guidance. 

The dose of this medication is dependent on your medical condition, physical size, and response to treatment. Do not increase the dose or use this medication more frequently or for longer periods than prescribed. Doing so will not expedite recovery and may increase your vulnerability to side effects. 

If you experience vomiting after taking a dose, do not consume another dose at that moment. Take your subsequent dosage at the scheduled time. 

Given that this drug may be absorbed via the skin and lungs and could cause harm to an unborn child, pregnant or potentially pregnant women should not come into contact with this medication or inhale the dust emanating from the tablets. 

Side Effects 

Allergic Reaction

In the event of an allergic reaction to Xeloda or severe skin reactions, such as a fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling, seek emergency medical help immediately. 

Severe Side Effects

Discontinue the use of Xeloda and contact your doctor without delay if you experience any of the following: 

• Severe diarrhea 
• Bloody diarrhea accompanied by severe abdominal pain and fever 
• Severe nausea or loss of appetite leading to reduced food intake 
• Vomiting more than once within 24 hours 
• A temperature exceeding 100.5 degrees Fahrenheit 
• Mouth ulcers or sores, redness or swelling of the mouth or tongue, difficulty eating or swallowing 
• Jaundice (yellowing of the skin or eyes) 
• Symptoms of dehydration, such as excessive thirst, inability to urinate, profuse sweating, or hot and dry skin 
• “Hand and foot syndrome” – characterized by pain, tenderness, redness, swelling, blistering, or peeling skin on the hands or feet 
• Cardiac issues, including chest pain, irregular heartbeats, swelling in the lower legs, rapid weight gain, feeling lightheaded or short of breath 
• Low blood cell counts, including fever, chills, fatigue, mouth or skin sores, easy bruising, abnormal bleeding, pale skin, cold hands and feet, lightheadedness, or shortness of breath 

Common Side Effects

Common side effects associated with Xeloda may include: 

• Nausea, vomiting, diarrhea, and stomach discomfort 
• Fatigue and weakness 
• Hand and foot syndrome 
• Jaundice 

Cautions 

Prior to taking capecitabine, inform your doctor or pharmacist of any allergies you have to this medication, 5-fluorouracil or other allergens. This drug may contain inactive components that can lead to allergic reactions or other problems. 

Disclose your medical history, particularly if you have a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD), blood disorders, heart conditions such as heart failure and coronary artery disease, kidney disease, or liver problems. 

Capecitabine may increase the risk of getting infections or worsen existing ones. To prevent the spread of infections, avoid contact with individuals who have contagious diseases like chickenpox, flu, and measles. In case of exposure to an infection or for further details, consult your physician. 

Inform your health care professional about capecitabine usage before undergoing any immunizations/vaccinations. Stay away from people who have recently taken live vaccines, such as flu vaccines that are inhaled via the nose. 

This drug can cause dizziness, and alcohol or marijuana may enhance the dizziness effect. To avoid accidents, do not drive, operate machinery, or do any activity that requires alertness until you feel stable. Limit alcohol consumption and consult your doctor if you are using marijuana (cannabis). 

Before surgery, let your doctor or dentist know about all the products you use, including prescription medications, non-prescription drugs, and herbal supplements. 

Older adults may experience more severe side effects from this medication, notably nausea, vomiting, diarrhea, and hand-foot syndrome. 

Since this drug can enter the body through the skin and lungs and potentially harm a developing fetus, pregnant women or women planning to get pregnant should not handle this medication or inhale the dust from the tablets.