Indications 

Valcyte is a prescribed medication indicated for treating cytomegalovirus (CMV) eye infections in individuals with acquired immunodeficiency syndrome (AIDS).  

Valcyte also serves as a preventive measure against CMV infection in patients who have undergone kidney, heart, or kidney-pancreas organ transplantation. 

As an antiviral drug, Valcyte functions by either halting the spread of CMV disease or inhibiting the growth of CMV. 

Uses and Dosage 

Before taking Valcyte and with every prescription refill, carefully review its medication guide and patient information leaflet. If you have any inquiries, do not hesitate to reach out to your doctor or pharmacist. 

Valcyte dosage and treatment duration depend on the patient’s medical condition, particularly kidney function. For children, dosing is contingent upon their body size, with the doctor monitoring their height and weight to ensure precise dosing. 

Typically, Valcyte is taken once or twice daily with food, as prescribed by the doctor. The tablet must be swallowed whole, not cut, crushed, or chewed. 

For optimal results, maintain a consistent level of this medication in your system by taking it at regular intervals. To aid in remembering, administer it at the same time(s) every day. 

Adhere to your doctor’s instructions and continue taking Valcyte as prescribed. Refrain from altering your dosage or discontinuing treatment unless expressly instructed by your doctor, as doing so without medical approval may elevate the risk of side effects or exacerbate the infection. 

After handling this medication, ensure thorough hand washing. Prevent contact with crushed or broken tablets on your skin, mucous membranes, and eyes, and avoid inhaling tablet dust. In case of contact, promptly wash the affected area with soap and water; if it comes into contact with your eyes, rinse them thoroughly with plain water. 

Side Effects 

Listed below are the potential adverse effects of Valcyte. Promptly inform your doctor if any of these symptoms last or worsen. 

Common Side Effects 

• Fever, chills, fatigue, mouth sores, skin sores, easy bruising, unusual bleeding, feeling light-headed or short of breath 
• Pain or burning during urination 
• Nausea, vomiting, diarrhea 
• Headache 
• Tremors 
• Sleep difficulties (insomnia) 
• Cold symptoms like stuffy nose, sneezing, and sore throat 

Serious Side Effects 

• Seizures 
• Pain or swelling near the transplanted organ 
• Kidney issues:  
  • Little or no urination 
  • Painful or difficult urination 
  • Swelling in the feet or ankles 
  • Fatigue 
  • Shortness of breath 
• Signs of infection: 
  • Fever 
  • Chills 
  • Fatigue 
  • Flu-like symptoms 
  • Feeling light-headed  
  • Short of breath 
  • Mouth sores 
  • Skin sores 
  • Pale skin 
  • Cold extremities 
  • Easy bruising 
  • Unusual bleeding (nose, mouth, vagina, or rectum) 

Call your doctor immediately if you experience any of the serious side effects mentioned above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Valcyte may occur. Immediate medical attention is necessary upon observing any indications of an allergic response, including: 

• Hives 
• Difficulty in breathing 
• Face, lips, tongue, or throat itching or swelling 

Not all side effects of Valcyte are included in this list. Tell your doctor promptly if any unlisted effects are encountered. 

Cautions 

Before initiating Valcyte treatment, inform your doctor of any known allergies, particularly to valganciclovir, ganciclovir, or acyclovir. 

Seek further guidance from your pharmacist about Valcyte, as it may contain inactive ingredients that can trigger allergic reactions or other complications. 

To ensure Valcyte is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Kidney problems (e.g., kidney dialysis) 
• Low blood cell count (red or white blood cells, platelets) 
• Radiation therapy 

Some products may interact with Valcyte, including didanosine, imipenem/cilastatin, and maribavir. To mitigate the risk of such drug interaction, inform all your healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements. 

Valganciclovir closely resembles ganciclovir. Avoid the concurrent use of medications containing ganciclovir while taking Valcyte.  

If you are on medications that affect bone marrow or kidney function (e.g., cancer chemotherapy, trimethoprim/sulfamethoxazole, zidovudine, cyclosporine), your healthcare provider will carefully supervise and modify your treatment to minimize potential severe side effects. 

Inform your healthcare provider about your Valcyte usage before receiving any immunizations. Refrain from interacting with individuals who have recently undergone live vaccinations, like the nasal flu vaccine. 

The use of Valcyte increases susceptibility to infections and exacerbates existing ones. Avoid contact with individuals carrying highly contagious infections like chickenpox, COVID-19, measles, or flu. Consult your physician if you have encountered an infection or require further information. 

Valcyte can induce drowsiness, dizziness, instability, confusion, decreased alertness, or seizures. Refrain from driving or operating machinery until you are aware of the medication’s impact on you. 

Valcyte does not prevent disease transmission. Avoid unprotected sex, sharing razors or toothbrushes, and inquire with your doctor about HIV transmission prevention during sexual activity. Never share drugs or medicine needles, as it is never safe. 

Pregnant or potentially pregnant women should avoid handling Valcyte due to potential harm to an unborn child. 

During pregnancy, take Valcyte only if necessary after discussing the risks and benefits with your doctor. Women of childbearing age should undergo a pregnancy test before starting treatment. 

To prevent pregnancy, men with female partners should use effective barrier protection during all sexual activity during treatment and for at least 90 days after treatment cessation.  

Women of childbearing age taking Valcyte should use reliable contraception methods during treatment and at least 30 days after treatment completion, with further details available through consultation with their doctor. 

Inform your healthcare provider of your breastfeeding status and refrain from breastfeeding while taking Valcyte. Consult with your doctor regarding the appropriate time to resume breastfeeding after discontinuing this medication.