Indications 

Plecanatide is indicated for the management of chronic idiopathic constipation and irritable bowel syndrome with constipation. Its mechanism of action involves augmenting intestinal fluid volume and facilitating the transit of ingested food. By promoting improvements in stool consistency and reducing symptoms such as abdominal discomfort and incomplete defecation, Plecanatide may aid in the amelioration of associated conditions. 

Uses and Dosage 

The medication should be taken orally, with or without food, once daily in accordance with the instructions provided by your physician. 

In cases where swallowing the tablet poses a challenge, you can crush the tablet and mix the resulting powder with a teaspoonful of room-temperature applesauce. The mixture should be consumed promptly, and any residual quantity should not be preserved for future usage. 

Alternatively, the tablet may be dissolved in an ounce (30 milliliters) of room-temperature water in a cup. The mixture should be swirled for at least 10 seconds before ingestion. If any remnants of the tablet remain in the cup, an additional ounce (30 milliliters) of water should be added to the cup, swirled for 10 seconds, and consumed immediately to ensure the complete dose is administered. If the medication is being administered through a tube into the stomach (nasogastric or gastric tube), your healthcare provider should furnish you with comprehensive instructions on how to administer the water mixture. 

Side Effects 

Seek medical assistance immediatly in the event that you experience an allergic reaction to Trulance, including: 

• Hives 
• Breathing difficulties 
• Swelling of the face, lips, tongue, or throat 

Diarrhea is a commonly observed side effect of Trulance usage. If the diarrhea is severe, discontinue the medication and contact your healthcare professional without delay. 

This is not an exhaustive list of potential side effects associated with Trulance. Other side effects may arise that are not listed here. You should consult with your doctor to receive medical guidance in the event of any adverse reactions. 

Cautions 

Prior to initiating plecanatide treatment, inform your healthcare provider or pharmacist of any preexisting allergies you may have, including allergies to plecanatide or any other allergens. This medication may contain inactive ingredients that can elicit allergic reactions or other issues. To obtain further information on this matter, please consult your pharmacist. 

Apprise your healthcare provider or pharmacist of your medical history, particularly if you have a history of stomach or intestinal blockages. 

If you are scheduled for surgery, inform your physician or dentist of all the products you are using, including prescription medications, nonprescription drugs, and herbal supplements.