Indications 

Trandate is a prescribed medication used to manage hypertension (elevated blood pressure). It can be administered as a standalone treatment or in conjunction with other antihypertensive medications, particularly thiazide and loop diuretics. 

As a dual-action alpha and beta-blocker, Trandate works by inhibiting the impact of specific naturally occurring chemicals in the body, such as epinephrine, on both the heart and blood vessels. This mechanism reduces heart rate, blood pressure, and cardiac stress. 

Uses and Dosage 

Before taking Trandate and with every prescription refill, carefully review its medication guide and patient information leaflet. Seek guidance from your healthcare provider or pharmacist if you have any inquiries. 

The prescribed dosage of this medication is contingent upon the patient’s medical condition and their response to treatment. 

To minimize the potential for adverse effects, your doctor may advise commencing treatment with Trandate at a conservative dose and incrementally adjusting it. Adhere closely to your doctor’s guidance in this regard. 

Typically, Trandate is taken twice daily. It can be consumed with or without food, but it is crucial to select one method and consistently adhere to it for each dose. 

For optimal results, take this medication exactly as directed at the same times each day. 

Continue taking Trandate consistently, even if you are in good health, as high blood pressure often does not present noticeable symptoms. 

Inform your healthcare provider if your condition does not show improvement or worsens, such as persistent high or increasing blood pressure readings. 

Side Effects 

Listed below are the potential adverse effects of Trandate. Should any of these effects last or worsen, promptly notify your doctor. 

Common Side Effects 

• Dizziness, drowsiness, or fatigue 
• Nausea or vomiting 
• Sudden warmth, skin redness, or sweating 
• Numbness 
• Tingling sensation on the scalp 

Serious Side Effects 

• Feeling lightheaded, with a risk of fainting 
• Slow heart rate, weak pulse, fainting, or slow breathing (which may result in cessation of breathing). 
• Shortness of breath, even with minor physical activity, along with swelling and rapid weight gain 
• Severe headache, blurred vision, pulsing sensation in neck or ears 
• Symptoms of liver problems: 
• Diminished appetite 
• Upper right abdominal pain 
• Flu-like symptoms 
• Itching 
• Dark urine 
• Jaundice (yellowing of skin or eyes) 

Call your doctor right away if you experience any of the serious side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Trandate may occur. Prompt medical assistance is necessary upon observing any indications of an allergic response, including: 

• Rash 
• Swelling, especially in the face, lips, tongue, or throat 
• Difficulty breathing 

Not all side effects of Trandate are included in this list. Report to your doctor if any unlisted effects occur. 

Cautions 

Before starting treatment with Trandate, inform your doctor of any known allergies, particularly to labetalol. 

Consult your pharmacist for additional information about Trandate, as it may contain inactive ingredients that may lead to allergic reactions or other complications. 

To ensure Trandate is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Heart conditions (e.g., heart failure, bradycardia, second- or third-degree atrioventricular block) 
• Respiratory issues (e.g., asthma, chronic bronchitis, emphysema) 
• Kidney problems 
• Liver disorders 
• Hyperthyroidism (overactive thyroid) 
• Severe allergic reactions, potentially requiring epinephrine 
• Circulatory disorders (e.g., Raynaud’s disease, peripheral vascular disease) 
• Mental or mood disorders (such as depression) 
• Specific muscle disorder (myasthenia gravis) 
• Particular eye conditions (cataracts, glaucoma) 

Some products may interact with Trandate, including cimetidine and fingolimod. To lower the risk of such drug interactions, notify all your healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements. 

Certain products may contain components that could elevate heart rate or blood pressure. Inform your pharmacist about all the products you are utilizing and inquire about their safe usage, particularly in the case of cough and cold remedies, dietary supplements, or NSAIDs like ibuprofen and naproxen. 

Trandate has the potential to disrupt specific medical and lab tests, potentially leading to inaccurate results. Ensure that laboratory personnel and all your healthcare providers are aware of your use of this medication. 

Inform your eye surgeon about your prior or current use of Trandate, as it may impact your pupils, even if you have discontinued its use. 

Trandate may affect blood sugar levels in people with diabetes. Monitoring blood sugar levels and informing the doctor of any changes is recommended. Adjustments to medication, exercise, and diet may be necessary. 

The use of Trandate may result in drowsiness. Avoid driving or operating machinery until you have assessed its impact on your ability to function. 

Trandate use may result in dizziness, lightheadedness, and fainting if you rise abruptly from a prone position. This is particularly prevalent during the initial stages of usage. To prevent this issue, gradually rise from bed by placing your feet on the ground for a few minutes before standing upright. 

Elderly individuals may experience heightened sensitivity to the adverse effects of Trandate, such as dizziness and lightheadedness. Consequently, these effects may elevate the likelihood of falls. 

The use of Trandate during pregnancy may lead to reduced blood pressure, decreased blood sugar levels, slowed heart rate, or respiratory difficulties in newborns. Notify your healthcare provider if you are currently pregnant or planning to conceive. 

Labetalol can be transferred to breast milk, and the impact on a breastfeeding baby is uncertain. Prior to nursing, consult your healthcare provider.