Indications 

Synarel Nasal Spray is a prescription medication used primarily in women to treat a condition called endometriosis, where the tissue that normally lines the inside of the uterus grows in the wrong place.  

Synarel Nasal Spray contains nafarelin acetate, which is a synthetic hormone analogue. It works by suppressing the production of certain hormones in the body, specifically the gonadotropin-releasing hormone (GnRH). This helps to reduce the growth of the endometrial tissue and alleviate symptoms associated with endometriosis. 

Use and Dosage 

Synarel Nasal Spray is intended for administration as a spray to the nasal mucosa. Use the spray as directed by your doctor, usually twice daily (about every 12 hours). If you are using more than 1 spray at a time, wait 30 seconds between each spray.  

Here is a general guide on how to use Synarel Nasal Spray: 

1. Before using the nasal spray for the first time, you may need to prime the pump. Follow the specific instructions provided with your medication to prime the pump. 
2. Gently blow your nose to clear your nasal passages before using the spray. This helps ensure proper absorption of the medication. 
3. Shake the Synarel Nasal Spray bottle gently to ensure the contents are mixed well. 
4. Remove the protective cap from the bottle and hold the bottle upright.  
5. Tilt your head slightly forward and insert the nozzle into one nostril. Close the other nostril by pressing your finger against it. 
6. Press down on the pump to release one spray of medication into the nostril. Breathe in gently through your nose as you spray to help the medication reach deep into your nasal passages. 
7. Repeat the process for the other nostril, using the same steps. 
8. After each use, wipe the nozzle with a clean tissue or cloth and replace the protective cap. 

Use the spray exactly as prescribed by the doctor. For it to be effective, it must be used regularly without interruption. If you miss a dose of the spray, contact your doctor or pharmacist for advice. Do not take a double dose to make up for a missed one. 

Side Effects 

Common Side Effects

• Acne 
• Appetite changes (increased/decreased) 
• Breast pain 
• Changes in breast size (enlarged or reduced) 
• Changes in taste 
• Constipation 
• Dandruff 
• Change in sexual desire 
• Diarrhea 
• Dizziness 
• Dry nose 
• Dry skin 
• Excessive sweating 
• Feeling of “fullness” 
• Hair loss 
• Headache 
• Hot flashes 
• Increased hair growth, often abnormally distributed 
• Irritation to tissues inside the nose 
• Mood swings 
• Muscle pain 
• Nausea 
• Nervousness 
• Runny nose 
• Stomach irritation 
• Stopping of menstrual periods 
• Swelling of the feet or lower legs 
• Trouble sleeping 
• Vaginal dryness 
• Vomiting 
• Weakness 
• Weight changes (increase or decrease) 

Serious Side Effects  

• Abdominal pain 
• Bloating 
• Changes in sleep 
• Changes in weight 
• Decreased interest in activities 
• Diarrhea 
• Ear pain 
• Increased weight 
• Joint pain 
• Nausea 
• Nosebleeds 
• Pain during or after sexual intercourse 
• Palpitations (rapid, pounding heartbeat) 
• Poor concentration 
• Red eyes (conjunctivitis) 
• Skin rash 
• Spinning sensation 
• Thoughts of suicide 
• Vaginal bleeding 
• Vomiting 

Cautions 

• Mental health effects: Synarel Nasal Spray may cause mental health effects such as emotional symptoms, including changes in mood or behavior. If you experience any changes in mood, depression, or other psychiatric symptoms, inform your healthcare provider. 
• Bone mineral density: Long-term use of Synarel Nasal Spray may lead to a decrease in bone mineral density. It may increase the risk of osteoporosis or bone fractures, especially in women who have additional risk factors for bone loss.  
• Pregnancy and breastfeeding: Synarel Nasal Spray is not recommended for use during pregnancy as it may harm the developing fetus. Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 
• Liver function: Synarel Nasal Spray may affect liver function. If you have a history of liver disease or liver dysfunction, inform your healthcare provider before using the spray. 
• Allergic reactions: Some individuals may have an allergic reaction to Synarel Nasal Spray. If you experience symptoms such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention. 
• Hormonal imbalances: Synarel Nasal Spray works by temporarily suppressing the production of certain hormones. This may lead to hormonal imbalances, such as changes in menstrual bleeding patterns or temporary cessation of menstruation. 
• Ovarian cysts: Synarel Nasal Spray may cause the development or worsening of ovarian cysts. If you experience pelvic pain, swelling, or discomfort, contact your healthcare provider. 
• Interactions with other medications: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Certain medications may interact with Synarel Nasal Spray, potentially affecting its effectiveness or increasing the risk of side effects. 
• Nasal irritation: Some individuals may experience nasal irritation, dryness, or discomfort while using Synarel Nasal Spray. If you experience persistent or severe nasal symptoms, consult your healthcare provider. 
• Driving and operating machinery: Synarel Nasal Spray may cause dizziness, drowsiness, or blurred vision in some individuals. If you experience these side effects, avoid driving or operating machinery until you know how the medication affects you.