Indications 

Steglatro, known by its generic name ertugliflozin, is an oral medication that is indicated for the improvement of glycemic control in individuals diagnosed with type 3 diabetes mellitus.  

This medication is typically used in conjunction with proper diet and exercise regimens. By effectively managing elevated blood sugar levels, the risk of complications associated with diabetes such as stroke, heart attack, blindness, nerve damage, sexual dysfunction, and limb loss can be reduced. 

Uses and Dosage 

Prior to initiating treatment with ertugliflozin,  carefully review the Medication Guide that is provided to you by your pharmacist. Review this guide before commencing treatment and each time a refill is obtained. Should any questions or concerns arise, please consult with your physician or pharmacist for clarification. 

Administer this medication orally as instructed by your healthcare provider, with or without food, typically once daily in the morning. The dosage prescribed is dependent on your medical condition and your response to treatment. 

Consistent usage of this medication is imperative in order to achieve optimal therapeutic outcomes. Take the medication at the same time each day to facilitate adherence. 

Should your medical condition fail to improve or worsen, such as your blood sugar levels being too high or too low, inform your physician immediately. 

Side Effects 

Severe Side Effects

Seek immediate medical attention if you experience any of the following: 

• Signs of an allergic reaction to Steglatro such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat 
• Signs of a genital infection (penis or vagina) such as burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, and feeling unwell. These symptoms may worsen quickly 

Contact your doctor immediately if you experience any of the following: 

• New pain, tenderness, sores, ulcers, or infections in your legs or feet 
• Little or no urination 
• Symptoms of ketoacidosis, which include nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing 
• Symptoms of low blood sugar, which include headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, feeling jittery 
• Dehydration symptoms such as dizziness, weakness, feeling light-headed, or the feeling that you might pass out 
• Signs of a bladder infection such as pain or burning during urination, increased urination, blood in urine, fever, pain in pelvis or back 

Note that some side effects of Steglatro may be more common in older adults. 

Common Side Effects  

• Vaginal odor, discharge, or itching 
• Redness, itching, swelling, rash, discharge, or pain in the skin around the penis 
• Urinating more than usual 

Caution 

Prior to taking ertugliflozin, kindly inform your healthcare provider or pharmacist if you are allergic to it or if you have any other allergies. This medication may contain inactive ingredients that can result in allergic reactions or other problems. For more details, speak with your pharmacist. 

Before using this medication, inform your healthcare provider or pharmacist about your medical history, particularly if you have had kidney disease/failure (dialysis), dehydration, history of yeast infections in the vagina or penis, use/abuse of alcohol, low blood pressure, blocked or narrowed blood vessels, usually in the leg, nerve problems (such as diabetic peripheral neuropathy), foot sores or ulcers, or amputation. 

Due to extremely low or high blood sugar levels, you may experience blurred vision, dizziness, or drowsiness. Do not operate machinery, drive, or engage in any activity that requires alertness until you can perform them safely. 

While taking this medication, limit your alcohol intake because it can increase the risk of developing low blood sugar and high ketone levels. 

Your body may experience difficulty controlling blood sugar when under stress (such as due to fever, infection, injury, or surgery). If you are unable to eat or are eating less due to any of these conditions or any illness, it can lead to high ketone levels while taking this medication. Consult your healthcare provider because this may necessitate changes in your treatment plan, medications, or blood sugar or ketone testing. 

Inform your doctor or dentist of all products you use, including prescription drugs, nonprescription drugs, and herbal products before undergoing any surgery. 

The side effects of this medication may be more pronounced in older adults, especially dizziness/fainting (usually when standing), dehydration, and kidney disease. 

During pregnancy, use this medication only when necessary. Discuss the risks and benefits with your doctor. 

Pregnancy may lead to or worsen diabetes. While pregnant, talk with your doctor about managing your blood sugar. Your diabetes treatment, including diet and medications such as insulin, may need to be modified during pregnancy.