Indications 

Sporanox Oral Solution is a prescription medication used to treat fungal infections in the mouth, throat, and/or gullet. It is commonly used to treat various fungal infections, including candidiasis (yeast infections) of the mouth, throat, and esophagus, and certain systemic fungal infections. 

Sporanox contains an active substance called Itraconazole. Itraconazole belongs to a class of medications known as azole antifungals. It works by inhibiting the growth of fungi that cause infections. When taken orally, the active ingredient, itraconazole, is absorbed into the bloodstream and distributed throughout the body. It then targets and interferes with the production of ergosterol, a key component of fungal cell membranes. This disruption weakens the fungal cells, leading to their death and eliminating the infection. 

Use and Dosage 

Sporanox Oral Solution should be taken on an empty stomach, usually at least one hour before or two hours after a meal. Avoid drinking grapefruit juice while taking Sporanox Oral Solution, as it may increase the levels of itraconazole in the body. 

Shake the bottle well before each use to ensure proper mixing of the solution. Use the provided dosing syringe or measuring cup to measure the correct amount of solution. 

The specific dosage and duration of treatment with Sporanox Oral Solution may vary depending on the type and severity of the fungal infection. For instance: 

• Oropharyngeal Candidiasis: The usual recommended dosage is 200mg (20mL) daily for 12 weeks. For fluconazole-resistant cases, the dosage may be 100mg (10mL) twice daily. 
• Esophageal Candidiasis: The usual recommended dosage is 100mg (10mL) daily. In some cases, doses up to 200mg per day may be used. 

If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. 

Side Effects 

Common Side Effects  

• Constipation 
• Decreased sexual desire 
• Depression 
• Diarrhea 
• Fever 
• Gas or bloating 
• Hair loss 
• Headache 
• Heartburn 
• Inability to get or keep an erection 
• Joint pain 
• Missed or irregular menstrual periods 
• Muscle pain or weakness 
• Nervousness 
• Runny nose and other cold symptoms 
• Stomach pain 
• Sweating 
• Unpleasant taste 

Serious Side Effects 

• Blistering or peeling skin  
• Dark urine 
• Difficulty breathing or swallowing 
• Excessive tiredness 
• Feelings of numbness 
• Hearing loss 
• Hoarseness 
• Inability to control urination or urinating more than usual 
• Loss of appetite 
• Nausea 
• Pale stools 
• Rash, hives, or itching 
• Ringing in the ears 
• Swelling of the face, throat, tongue, lips, eyes, hands, ankles, or lower legs 
• Tingling, pricking, burning, or creeping on the skin 
• Vomiting 
• Yellowing of the skin or eyes 

Cautions 

• Contraindications: Sporanox Oral Solution is contraindicated in individuals with hypersensitivity to itraconazole or any of its components. It should also not be used in patients with a history of congestive heart failure, including those with a history of heart failure symptoms or structural heart disease. 
• Drug Interactions: Itraconazole can interact with various medications, including certain anticoagulants, anticonvulsants, statins, benzodiazepines, and immunosuppressants. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, to avoid potential drug interactions. 
• Liver Impairment: Sporanox Oral Solution should be used with caution in patients with liver impairment.  
• Heart Problems: Sporanox Oral Solution may have the potential to cause or worsen heart problems. It should not be used in patients with a history of congestive heart failure, and caution is advised in individuals with other heart conditions.  
• Pregnancy and Breastfeeding: Sporanox Oral Solution should not be used during pregnancy unless the potential benefits outweigh the risks. Do not use it while breastfeeding, as itraconazole may pass into breast milk. 
• Allergic Reactions: Some individuals may experience allergic reactions to Sporanox Oral Solution. If you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention. 
• Gastrointestinal Issues: Sporanox Solution may cause gastrointestinal side effects such as nausea, vomiting, abdominal pain, and diarrhea. If you experience severe or persistent symptoms, inform your healthcare provider. 
• Renal Impairment: Sporanox Solution should be used with caution in individuals with renal impairment. Adjustments to the dosage may be necessary, and close monitoring of kidney function is recommended. 
• Nervous System Effects: Itraconazole has been associated with rare cases of peripheral neuropathy (nerve damage) and reports of dizziness or disturbances in vision. If you experience any neurological symptoms, notify your healthcare provider. 
• Skin Reactions: In rare cases, Sporanox Solution may cause skin reactions such as rash, itching, and photosensitivity (increased sensitivity to sunlight). Use appropriate sun protection measures and seek medical attention if you develop severe or persistent skin reactions. 
• Fertility and Hormonal Effects: Itraconazole has been reported to have effects on male fertility in animal studies. While the clinical significance in humans is unclear, consider the potential effects on fertility before starting treatment. 
• Children and Elderly: Sporanox Solution should be used with caution in pediatric and geriatric populations. Dosage adjustments and careful monitoring may be necessary, as these populations may be more susceptible to certain side effects. 
• Driving and Operating Machinery: Itraconazole may cause dizziness or blurred vision in some individuals. If you experience these side effects, avoid driving or operating machinery until you know how the medication affects you.