Indications 

Seroquel (quetiapine) is an atypical antipsychotic medication for the treatment of bipolar disorder, manic episodes, depression, and schizophrenia in individuals aged 10 years and older.  

This prescription drug functions by acting on dopamine, a neurotransmitter in the brain that regulates movement, thoughts, emotions, arousal, and reward. Too much dopamine in the brain can lead to several symptoms, including manic episodes in individuals with schizophrenia.  

Seroquel counteracts this effect by blocking certain brain regions where dopamine acts and reducing its overactivity, thus calming the brain. Moreover, Seroquel blocks serotonin, another brain chemical that is involved in mood, balance, and memory regulation.  

Too much serotonin can trigger schizophrenia symptoms, depression, and movement control issues. Seroquel balances these neurotransmitters in the brain to alleviate psychotic episodes and depression symptoms. 

Uses and Dosage 

Before taking quetiapine, read and understand the medication guide and patient information leaflet provided by your pharmacist. If you have any questions, consult your doctor or pharmacist. 

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily with or without food. For depression associated with bipolar disorder, take this medication once daily at bedtime. 

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Inform your doctor and pharmacist of all the products you use, including prescription drugs, nonprescription drugs, and herbal products. 

Your doctor may instruct you to start this medication at a low dose and gradually increase it to reduce the risk of side effects. Follow your doctor’s instructions carefully and take this medication regularly to get the most benefit from it. 

Do not increase your dose or use this drug more often or for longer than prescribed. Doing so will not improve your condition faster, but instead, it will increase your risk of side effects. 

Side Effects 

Allergic Reactions

Seek emergency medical assistance immediately if you experience an allergic reaction to Seroquel. Symptoms may include: 

• Hives 
• Difficulty breathing 
• Swelling of the face, lips, tongue, or throat 

Severe Side Effects

Inform your doctor about any new or worsening symptoms such as: 

• Changes in mood or behavior 
• Anxiety, panic attacks 
• Sleep issues 
• Impulsivity 
• Irritability 
• Hostility 
• Aggression 
• Restlessness 
• Hyperactivity (mental or physical) 
• Increased depression 
• Suicidal thoughts 
• Self-harm ideation 

Contact your healthcare provider right away if you experience any of the following symptoms: 

• Uncontrolled muscle movements in the face, such as chewing, lip smacking, frowning, tongue movement, blinking or eye movement 
• Mask-like appearance of the face, difficulty swallowing, or problems with speech; 
• Feeling light-headed and at risk of passing out 
• Blurred vision, tunnel vision, eye pain, or seeing halos around lights 
• Severe nervous system reaction, such as very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, or fainting 
• High blood sugar, which may cause increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, or weight loss 
• Low blood cell counts, which may cause sudden weakness or ill feeling, fever, chills, cold or flu symptoms, cough, sore throat, red or swollen gums, painful mouth sores, skin sores, or trouble breathing 

Common Side Effects 

• Speech problems 
• Dizziness, drowsiness, or tiredness 
• Lack of energy 
• Fast heartbeats 
• Stuffy nose 
• Increased appetite or weight gain 
• Upset stomach, vomiting, or constipation 
• Dry mouth 
• Problems with moving 

Caution 

Follow your doctor’s instructions when taking Seroquel, and do not exceed the prescribed dosage or use the medication for longer than recommended. The occurrence of a serious movement disorder that may be irreversible is possible with high doses or prolonged use. Symptoms of this disorder may include uncontrollable muscle movements or tremors. 

In some cases, young individuals may experience suicidal thoughts when initially using Seroquel. Be attentive to any alterations in your mood or symptoms, and report any new or worsening symptoms to your doctor. 

Continue taking this medication as prescribed by your doctor, as untreated mental and mood disorders, such as schizophrenia, bipolar disorder, and depression, can be severe conditions. If you are considering pregnancy, currently pregnant, or suspect that you may be pregnant, have a discussion with your doctor regarding the potential benefits and risks associated with taking this medication during pregnancy. Stopping or adjusting your dosage without medical advice may result in the worsening of your condition.