Indications 

Sandomigraine, also known as Pizotifen, is a medication used for the prophylactic management of migraines. It is a serotonin antagonist that helps reduce the frequency and severity of migraine attacks. 

Sandomigraine works by blocking the action of serotonin, a neurotransmitter involved in the development of migraines. By reducing the levels of serotonin, it helps prevent the blood vessels in the brain from becoming dilated and causing migraines. 

Use and Dosage 

Pizotifen comes in the form of tablet to take it by mouth usually taken orally, as directed by the doctor, with or without food. The dosage and frequency of administration will be determined by your healthcare provider based on your individual needs and response to the medication. 

Do not wait for a migraine before taking the medicine to treat the pain. Take Pizotifen 0.5mg regularly to prevent a migraine or reduce the severity of the migraine. 

The usual doses of Pizotifen 0.5mg or 1.5mg Tablets Adults are as follows: 0.5mg tablets three times daily. Your doctor may increase the number of tablets you take up to a maximum of 4.5mg (nine 0.5mg tablets) if required. You may have been told to take your tablets daily as a single dose or you may have to take three smaller doses. Do not take more than 3mg in a single dose. Do not exceed the maximum daily dose of 4.5mg. 

The usual doses of Pizotifen 0.5mg Tablets Children are as follows: For children over 2 years of age, at first this may be 0.5mg daily. This may be taken at night. The dose can be gradually increased to a maximum dose of 1.5mg daily (three 0.5mg tablets). The maximum single dose is 1mg (two 0.5mg tablets). 

Use Pizotifen tablet exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 4 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.  

Side Effects 

Common Side Effects 

• Dizziness 
• Drowsiness 
• Dry mouth 
• Fatigue 
• Increased appetite 
• Nausea 
• Weight gain 

Serious Side Effects 

• Aggressive behavior or agitation in children 
• Changes in sleep 
• Changes in weight 
• Dark urine 
• Decreased interest in activities 
• Diarrhea 
• Difficulty breathing 
• Hallucinations 
• Hives 
• Loss of appetite 
• Low blood pressure 
• Muscle and joint pain 
• Nausea 
• Pale stools 
• Poor concentration 
• Seizures  
• Sensation of tingling or prickling  
• Swelling of the throat or mouth 
• Thoughts of suicide 
• Vision changes 
• Vomiting 
• Weight loss 
• Yellowing of the skin or whites of the eyes 

Cautions 

• Epilepsy: the tablet should be used with caution in patients with epilepsy, as it may potentially worsen seizures. 
• Withdrawal symptoms: Abruptly stopping pizotifen can lead to withdrawal symptoms such as depression, tremor, nausea, anxiety, malaise, dizziness, and sleep disturbances.  
• Allergies: Sandomigraine should not be used if there is a known allergy to pizotifen or any of its ingredients. Inform your healthcare provider about any allergies you may have before starting this medication. 
• Pregnancy and breastfeeding: The safety of pizotifen during pregnancy and breastfeeding is not well-established. Discuss the potential risks and benefits with a healthcare professional before using this medication in these situations. 
• Children and adolescents: The safety and effectiveness of the tablet in children and adolescents have not been well-studied. Consult with a pediatrician before using this medication in this population. 
• Other medical conditions: Sandomigraine should be used with caution in patients with certain medical conditions, such as liver or kidney problems. 
• Driving and operating machinery: Sandomigraine may cause drowsiness or dizziness, which can impair your ability to drive or operate machinery. 
• Interactions with other medications: pizotifen may interact with other medications, including antidepressants, sedatives, antihistamines, and medications that affect blood clotting.  
• Glaucoma: Sandomigraine may increase the pressure within the eye, which can be problematic for individuals with glaucoma.  
• Urinary retention: Pizotifen may cause urinary retention, especially in individuals with a history of urinary problems.  
• Asthma and respiratory conditions: pizotifen may cause bronchospasm or worsening of respiratory symptoms in individuals with asthma or other respiratory conditions.  
• Alcohol and sedatives: Alcohol and sedatives can enhance the sedative effects of pizotifen. Avoid excessive alcohol consumption and discuss the use of other sedating medications with your healthcare provider.