Indications 

Protonix (pantoprazole sodium) is an oral medication that is indicated for the treatment of erosive esophagitis associated with gastroesophageal reflux disease (GERD) and pathological hypersecretory conditions, including Zollinger-Ellison syndrome.  

Its therapeutic effects include relieving symptoms such as persistent cough, heartburn, and difficulty swallowing, as well as preventing ulcers and esophageal cancer. 

As a proton pump inhibitor (PPI), Protonix works by inhibiting the final step in gastric acid production, thereby blocking basal and stimulated gastric acid secretion. The antisecretory effect of the medication can last for up to 24 hours. 

Uses and Dosage 

To ensure safe and effective use of this product, please carefully review the medication information leaflet before taking this oral PPI. Only take this medication if you fully understand the drug information and instructions provided in the guide. If you have any additional queries or need further medical advice, consult your doctor or pharmacist. 

This delayed-release tablet should be taken orally, usually once daily, with or without food. Swallow the tablet whole and drink a full glass of water immediately afterwards. Do not chew, crush, or divide the tablet, as it may impact its effectiveness. 

Take this oral tablet regularly and as directed by your healthcare provider. Establish a dosing schedule to ensure that you do not miss a dose. If you are prescribed other antacids, particularly sucralfate, take Protonix at least 30 minutes prior to avoid potential drug interactions. 

Do not adjust your dosage or length of treatment unless instructed by your healthcare provider, as it will depend on your medical condition and response to the medication. Additionally, do not discontinue this medication abruptly as it may worsen your medical condition. 

Side Effects 

Allergic Reactions 

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Call your doctor immediately if you experience: 

• Severe stomach pain 
• Watery or bloody diarrhea 
• Sudden pain or trouble moving your hip, wrist, or back 
• Bruising or swelling where intravenous pantoprazole was injected 
• Kidney problems such as:
  • Fever
  • Rash
  • Nausea
  • Joint pain
  • Urinating less than usual
  • Blood in your urine
  • Weight gain 
• Low magnesium including:
  • Dizziness
  • Fast or irregular heart rate
  • Tremors
  • Jerking muscle movements
  • Feeling jittery
  • Muscle cramps
  • Muscle spasms in your hands and feet
  • Cough or choking feeling 
• New or worsening symptoms of lupus such as:
  • Joint pain
  • Skin rash on your cheeks or arms that worsens in sunlight 

Talk with your doctor about the risk of developing stomach growths called fundic gland polyps when taking pantoprazole long-term. 

If you use pantoprazole for more than 3 years, you may develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition. 

Common Side Effects  

• Headache 
• Dizziness 
• Stomach pain, gas, nausea, vomiting, or diarrhea 
• Joint pain 
• Fever, rash, or cold symptoms (most common in children) 

Caution 

Prior to taking pantoprazole, inform your physician or pharmacist of any allergies you have to this medication, similar drugs (such as lansoprazole, omeprazole), or any other allergies. Inactive ingredients in this product may cause allergic reactions or other issues, so consult your pharmacist for further information. 

Before using this medication, inform your physician or pharmacist of your medical history, particularly if you have liver disease or lupus. 

Certain symptoms may be signs of a more serious condition. Seek medical attention immediately if you experience heartburn with lightheadedness, sweating, or dizziness, or chest/jaw/arm/shoulder pain (especially with shortness of breath and unusual sweating), or unexplained weight loss. 

Prior to undergoing surgery, disclose all medications you are using, including prescription drugs, nonprescription drugs, and herbal products, to your physician or dentist. 

Proton pump inhibitors (such as pantoprazole) may increase the risk of bone fractures, particularly with extended use, higher dosages, and in older adults. Consult your doctor or pharmacist regarding measures to prevent bone loss/fracture, such as using calcium supplements (such as calcium citrate) and vitamin D. 

Older adults may be more prone to the drug’s side effects, especially bone loss and fractures (see above), as well as C. difficile infection. This medication passes into breast milk. Consult your doctor before breastfeeding.