Indications 

Prometrium is a crucial female hormone that plays a pivotal role in regulating ovulation and menstruation. Its administration is particularly valuable in women who are not experiencing menstrual periods due to a deficiency in progesterone levels, but who have not yet undergone menopause.  

This medication is utilized to mitigate the risk of endometrial hyperplasia in postmenopausal women receiving estrogen hormone replacement therapy.  

Prometrium is not indicated for preventing heart disease or dementia, as its use may actually heighten the probability of developing these ailments. 

Uses and Dosage 

Prior to commencing use of this medication and upon receiving subsequent refills. Patient Information Leaflet, which is provided by the pharmacist, be thoroughly reviewed. Should any inquiries arise, seek guidance from your physician or pharmacist. 

In accordance with your doctor’s instructions, take this medication orally once daily, typically at bedtime.  

If experiencing difficulties in swallowing the pills, consume with a full glass of water while standing.  

Adhere to the prescribed dosing schedule meticulously, and direct any uncertainties to your healthcare provider. The dosage is determined by your medical condition and reaction to treatment. 

Please notify your physician in the event that your condition fails to improve or worsens. 

Side Effects 

Allergic Reactions

In the event of any allergic reactions, seek immediate medical assistance, if you experience the following symptoms: 

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Serious side effects may be caused by Prometrium, and you should contact your physician immediately if you experience any of the following: 

• Unusual vaginal bleeding 
• Pain or burning sensation during urination 
• Breast lump 
• Sudden vision issues, severe headache, or pain behind the eyes 
• Symptoms of depression, including:
  • Sleep issues
  • Weakness
  • Mood swings 
• Severe dizziness or drowsiness, confusion, spinning sensation, and shortness of breath 
• Symptoms of a heart attack, such as:
  • Chest pain or pressure
  • Pain spreading to your jaw or shoulder
  • Nausea
  • Sweating 
• Liver problems, such as:
  • Nausea
  • Upper stomach pain
  • Tiredness
  • Itching
  • Loss of appetite
  • Dark urine
  • Clay-colored stools
  • Yellowing of the skin or eyes (jaundice) 
• Signs of a stroke, including:
  • Sudden numbness or weakness (especially on one side of the body)
  • Severe headache
  • Slurred speech
  • Problems with speech or balance 
• Signs of a blood clot in the lungs, such as:
  • Chest pain
  • Sudden cough
  • Wheezing
  • Rapid breathing
  • Coughing up blood 
• Signs of a blood clot in your legs, such as:
  • Pain, swelling, warmth, or redness in one or both legs 

Common Side Effects 

• Drowsiness and dizziness 
• Breast pain 
• Mood changes 
• Headache 
• Constipation, diarrhea, and heartburn 
• Bloating and swelling in your hands or feet 
• Joint pain 
• Hot flashes 
• Vaginal discharge 

Caution 

Prior to commencing progesterone treatment, inform your physician or pharmacist about any allergic reactions you have experienced in the past or any existing allergies. The product may contain inactive elements, such as peanut oil, which can result in allergic reactions or other adverse effects. Consult your pharmacist for additional details. 

Disclose your medical history, particularly if you have a history of blood clots, bleeding in the brain, liver disease, unknown vaginal bleeding, missed abortion, cancer (especially breast or other female organs), kidney disease, obesity, heart disease, high blood pressure, seizures, migraine headaches, asthma, high cholesterol/fat levels, depression, diabetes, strokes, or lupus, before using this medication. 

This medication may induce dizziness or drowsiness. Consumption of alcohol or marijuana (cannabis) may exacerbate these symptoms. Do not operate machinery, drive or engage in activities that require alertness until safe to do so. Limiting alcoholic beverages is recommended, and if using marijuana (cannabis), discuss this with your doctor. 

Prior to undergoing surgery or remaining seated or bedridden for an extended period, such as during a long plane ride, notify your physician. Special precautions or medication discontinuation may be required due to the increased risk of blood clots.  

Smoking is not recommended while taking this medication as it further increases the risk of strokes, blood clots, high blood pressure, and heart attacks. 

Melasma, which appears as blotchy, dark areas on the face and skin, may be caused by this medication. Sun exposure may exacerbate this condition. Limit sun exposure, avoid tanning beds and lamps, and wear protective clothing and sunscreen when outdoors. 

This medication is safe for use during pregnancy only under the direction of your physician. Discuss the benefits and risks with your doctor. 

Consult your physician before breastfeeding, as this medication passes into breast milk.