Indications 

Prilosec is a medication belonging to the proton pump inhibitor class of drugs that works by decreasing the amount of acid production in the stomach.  

This is primarily prescribed to manage symptoms associated with gastroesophageal reflux disease (GERD) and other medical conditions triggered by excessive stomach acid.  

Omeprazole, the active ingredient in Prilosec, is used to facilitate the healing of erosive esophagitis, a condition that results from damage to the esophagus caused by stomach acid. 

Prilosec is often administered in conjunction with antibiotics to manage gastric ulcers resulting from infections with the bacterium Helicobacter pylori (H. pylori). 

Uses and Dosage 

For optimal effectiveness, Prilosec can be taken with or without food. However, taking it with a glass of water 30 to 60 minutes before a meal can help maximize its benefits. By doing so, the drug can be readily available in the body to prevent acid release and associated symptoms. 

Swallow the capsule whole and not to crush or chew it. Alternatively, you may open the capsule and sprinkle the contents on soft food or swallow the contents with a spoonful of applesauce. 

Depending on your condition, all dosage forms are generally taken once per day or as needed. Prescription Prilosec use varies and can range from two to eight weeks or more, as determined by your healthcare provider. 

Side Effects 

Prilosec may cause side effects, but most people do not experience serious problems. If you have any concerns or notice any changes, tell your doctor or pharmacist immediately. Here are some important points to keep in mind: 

Common Side Effects  

• Headaches and abdominal pain 

Let your doctor know if these symptoms persist or worsen. 

Severe Side Effects

This medication is prescribed because its benefits outweigh the risks for most patients. However, contact your doctor right away if you have serious side effects, such as: 

• Muscle spasms  
• Rash on your nose and cheeks 

Prilosec may rarely cause a severe intestinal condition caused by C. difficile bacteria. If you experience: 

• Diarrhea that doesn’t stop 
• Abdominal pain or cramping 

• Blood/mucus in your stool, contact your doctor immediately 

Do not use anti-diarrhea or opioid products. 

Long-term use of proton pump inhibitors like omeprazole can increase the risk of vitamin B-12 deficiency. Tell your doctor right away if you have: 

• Unusual weakness  
• Sore tongue 
• Numbness/tingling of the hands/feet 

Allergic Reactions

Although very rare, an allergic reaction to Prilosec can be serious. Seek medical help right away if you have: 

• Fever 
• Swollen lymph nodes 
• Rash 
• Itching/swelling (especially of the face/tongue/throat) 
• Severe dizziness 
• Trouble breathing 
• Changes in urination 

Caution 

Prior to taking omeprazole, inform your healthcare provider or pharmacist if you have an allergy to this medication or similar drugs like esomeprazole, lansoprazole, and pantoprazole, or if you have any other allergies.  

This medication may contain inactive components that can lead to allergic reactions or other complications. It is advised to consult your pharmacist for additional information. 

Inform your healthcare provider or pharmacist about your medical history, particularly if you have a history of liver disease or lupus. 

Seek immediate medical attention if you experience heartburn along with sweating, dizziness, or lightheadedness, chest/jaw/shoulder/arm pain (especially with shortness of breath or unusual sweating), or unexplained weight loss, as these symptoms could indicate a more severe condition. 

Before undergoing any surgical procedures, inform your doctor or dentist of all the products you are using, including prescription and nonprescription drugs, as well as herbal supplements. 

Proton pump inhibitors, including omeprazole, may increase the risk of bone fractures, particularly with extended use, higher doses, and in elderly patients. Speak with your healthcare provider or pharmacist about preventative measures to reduce the risk of bone loss or fractures, such as taking calcium and vitamin D supplements. 

Older adults may be more susceptible to the side effects of this medication, including bone loss and fractures, as well as C. difficile infections. 

Children may be more vulnerable to the side effects of this medication, such as fever, cough, and infections of the nose, throat, or airways. 

This medication should only be used during pregnancy if necessary. Discuss the risks and benefits with your healthcare provider.