Indications 

Prevalite is a prescribed medication used alongside diet to lower high levels of cholesterol in patients with primary hypercholesterolemia (elevated low-density lipoprotein (LDL) “bad” cholesterol) when diet alone is insufficient. 

Prevalite is also indicated for the treatment of pruritus (skin itching) in individuals suffering from excessive bile acid due to a specific form of liver or bile duct disease known as partial biliary obstruction. 

As a bile acid sequestrant, Prevalite acts by absorbing and binding with bile acids in the intestine to form an insoluble complex, which is then excreted in the feces. This process helps remove bile acids from the body and leads to lower cholesterol levels in the blood. 

In patients with partial biliary obstruction, Prevalite helps alleviate itching by reducing the levels of excess bile acids in the bloodstream, decreasing the deposition of bile acids in the skin tissues. 

Uses and Dosage 

Before taking Prevalite and with every prescription refill, carefully review its medication guide and patient information leaflet. Consult your healthcare provider or pharmacist if you have any questions or concerns. 

Prevalite dosage is individualized based on the patient’s medical condition and response to the treatment.  

To minimize side effects, your doctor may instruct you to begin this medication at a low dose and gradually increase it. Carefully follow your doctor’s instructions. 

Prevalent comes in a powder form to be mixed with fluids or fruits. It is typically taken  

1 to 2 times a day before a meal and/or at bedtime.  

To prepare Prevalent, follow these steps: 

1. Use the provided scoop to measure the correct dosage required. 
2. Mix the measured powder in at least 2 to 6 ounces glass of water, milk, heavy or pulpy fruit juices (e.g., orange juice), or any other beverage and stir well. 
   • If using a carbonated beverage, mix the powder slowly in a large glass to prevent excessive foaming. 
3. Drink the mixture slowly. 
4. Rinse the glass with more of the chosen beverage and drink it to ensure you have taken all the powder. 

Alternatively, Prevalite powder can be mixed with applesauce, crushed pineapple, pureed fruit, or soup. Avoid heating the powder when mixing it with hot foods. 

For better taste and convenience, you can prepare a day’s worth of doses the night before and store them in the refrigerator. 

For optimal results, take Prevalite exactly as direct at around the same time each day. Seek your doctor’s approval before modifying the recommended dosage and frequency of intake. 

Continue taking Prevalite even if you feel well. Discontinuing its use should only be done after consulting with your doctor. 

Side Effects 

Listed below are the potential adverse effects of Prevalite. Tell your healthcare provider promptly if any of these symptoms persist or worsen. 

Common Side Effects 

• Mild constipation or diarrhea 
• Stomach pain, nausea, or loss of appetite 
• Bloating or gas 
• Irritation of the tongue 
• Itching or irritation around the rectal area 

Serious Side Effects 

• Ongoing or worsening constipation 
• Severe stomach pain 
• Blood in the urine 
• Black, bloody, or tarry stools 
• Easy bruising or unusual bleeding 

Inform your doctor right away if you experience any of the symptoms mentioned above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Prevalite may occur. Seek prompt medical help if any of the following indications of severe allergic reactions are noticed:  

• Hives 
• Face, lips, tongue, or throat swelling 
• Difficulty breathing 

Not all side effects of Prevalite are included in this list. Inform your doctor right away if any unlisted effects are observed. 

Cautions 

Before starting treatment with Prevalite, talk to your doctor if you have any known allergies, particularly to cholestyramine or other medications. 

Consult your pharmacist for other information, as Prevalite may contain inactive ingredients that can trigger allergies or other complications. 

To ensure Prevalite is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Constipation 
• Hemorrhoids 
• Kidney disease 

Many medications may interact with Prevalite, including warfarin, mycophenolate, and raloxifene. To reduce the risk of such drug interactions, inform all your healthcare providers about any current, newly initiated, or discontinued medications, including prescription and non-prescription drugs, vitamins, and herbal supplements. 

Prevalite can affect the absorption of other medications. Follow your doctor’s instructions and take your other medications either at least 1 hour before or 4 to 6 hours after taking Prevalite.  

Due to the potential interference of this medication with the absorption of specific nutrients (such as folic acid and fat-soluble vitamins A, D, E, and K), your doctor may recommend taking a multivitamin supplement.  

The use of Prevalite can potentially affect tooth surfaces. Avoid sipping the mixture slowly or holding it in your mouth for an extended period, as this can lead to tooth discoloration, enamel erosion, or tooth decay. Maintain regular brushing of your teeth while using this medication. 

Prevalite should be used during pregnancy only if necessary, as it may impact nutrient absorption. Consult your doctor to evaluate the risks and benefits of this medication. 

Cholestyramine is not expected to be excreted in breast milk, but it can potentially interfere with the absorption of specific nutrients. Before breastfeeding, seek advice from your healthcare provider.