Indications 

Parlodel is a prescribed medication indicated for alleviating symptoms associated with hyperprolactinemia (a hormonal imbalance characterized by an excessive amount of prolactin in the bloodstream), such as unwanted breast milk, irregular menstrual cycles, fertility challenges, reduced sperm count, and impaired sexual function. 

Parlodel is also indicated for the treatment of hyperprolactinemia resulting from specific prolactin-producing tumors, with the potential to induce tumor shrinkage. 

Furthermore, Parlodel is occasionally utilized in conjunction with surgical or radiation procedures to address acromegaly (excessive growth hormone) and to alleviate symptoms associated with Parkinson’s disease, including rigidity, tremors, muscle spasms, and impaired motor control.  

Classified as an ergot derivative with strong dopamine receptor agonist properties, Parlodel exerts its therapeutic effects by reducing prolactin levels to manage hyperprolactinemia, lowering growth hormone levels to address acromegaly, and stimulating movement-controlling nerves to treat Parkinson’s disease. 

Uses and Dosage 

Before taking Parlodel, and with each prescription refill, carefully review its medication guide and patient information leaflet. Consult your physician or pharmacist if you have any queries or concerns. 

The dosage of Parlodel depends on the patient’s medical condition and response to treatment. In cases of acromegaly, growth hormone levels are also considered. 

To minimize the risks of side effects, your doctor may advise starting with a low dose and gradually increasing it. Carefully follow your doctor’s instructions. 

Typically, Parlodel is taken once or twice daily with food, as directed by the doctor. Take it consistently at around the same time each day to optimize its effectiveness. 

Seek medical advice before discontinuing Parlodel. Abrupt cessation of this medication may worsen certain conditions and may also lead to withdrawal symptoms, such as anxiety, depression, confusion, fever, and muscle stiffness. Your doctor is likely to reduce your dosage gradually. 

Side Effects 

Listed below are the potential adverse effects of Parlodel. If any of them last or worsen, inform your doctor immediately. 

Common Side Effects 

• Dizziness 
• Headache 
• Hallucinations 
• Nausea 
• Constipation 
• Abnormal involuntary movements 

Serious Side Effects 

• Numbness, pain, and paleness or discoloration in fingers or toes (especially in cold weather) 
• Vision problems, constant runny nose 
• Chest pain, pain while breathing, rapid heart rate, rapid breathing, shortness of breath (especially when lying down) 
• Back pain, ankle or feet swelling, decreased or absence of urination 
• Confusion, hallucinations, fainting sensation 
• Involuntary muscle movements, loss of balance or coordination 
• Bloody or tarry stools, coughing up blood or vomiting resembling coffee grounds 

Inform your doctor right away if you experience any of the severe side effects above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Parlodel may occur. If any of the following symptoms listed below are observed, prompt medical attention should be sought: 

• Hives 
• Difficult breathing 
• Face, lips, tongue, or throat swelling 

Not all side effects of Parlodel are included in this list. Tell your physician right away if any unlisted effects are observed. 

Cautions 

Before starting treatment with Parlodel, inform your doctor of any known allergies, particularly to: 

• Bromocriptine 
• Other ergot medications (e.g., ergotamine, pergolide) 
• Other drugs 
• Any of the components of Parlodel tablets 

To ensure Parlodel is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Certain genetic enzyme disorders (galactose intolerance, lactase deficiency, glucose-galactose malabsorption) 
• Recent pregnancy, especially with high blood pressure 
• High or low blood pressure 
• Liver disease 
• Heart problems (e.g., coronary artery disease, heart attack, irregular heartbeat) 
• Mental/mood disorders (e.g., psychosis, depression, schizophrenia) 
• Stomach/intestinal issues (e.g., bleeding, ulcer) 
• Blood flow problems (e.g., peripheral vascular disease, Raynaud’s disease) 

Notify all healthcare providers about any current or newly initiated or discontinued medications, including prescription/non-prescription drugs, vitamins, and herbal supplements, as they may interact with Parlodel. 

Some of the products that may interact with Parlodel include: 

• Antipsychotic drugs (e.g., chlorpromazine, haloperidol, thioridazine) 
• Other ergot medications (e.g., ergotamine) 

The effectiveness of Parlodel can be influenced by other medications that impact its elimination from the body. Examples of such medications include: 

• Azole antifungals (e.g., itraconazole, ketoconazole) 
• Cobicistat 
• Macrolide antibiotics (e.g., clarithromycin, erythromycin) 
• Nefazodone 
• HIV protease inhibitors (e.g., lopinavir, ritonavir) 
• Telithromycin 

Review the labels of all your medications, including allergy or cough-and-cold products, as they may contain sedating ingredients. Consult your pharmacist to ensure the safe use of these products. 

Be sure to inform your doctor or pharmacist if you are taking any of the following products that may cause drowsiness: 

• Alcohol 
• Marijuana (cannabis) 
• Antihistamines (e.g., cetirizine, diphenhydramine) 
• Sleep or anxiety medications (e.g., alprazolam, diazepam, zolpidem) 
• Muscle relaxants (e.g., carisoprodol, cyclobenzaprine) 
• Opioid pain relievers (e.g., codeine, hydrocodone) 

Parlodel can induce daytime sleepiness, leading to unexpected episodes of falling asleep while engaging in regular activities like work, conversation, eating, or driving. Even if you feel awake, you may experience sudden bouts of sleepiness. Inform your doctor about any issues related to daytime drowsiness or sleepiness. 

If you experience heightened sexual urges, atypical urges to gamble, or other intense urges during Parlodel treatment, discuss this with your doctor. 

Adhere to your doctor’s guidance regarding the use of Parlodel if you are pregnant or planning to become pregnant. During pregnancy, a pituitary tumor in the mother may grow, and high blood pressure can also arise. This medication may pose risks if taken by a pregnant woman with high blood pressure. 

Parlodel is sometimes prescribed to women to regulate menstrual cycles and enhance fertility. Inform your doctor promptly upon becoming pregnant. Depending on individual circumstances, discontinuation of Parlodel may be necessary. 

If Parlodel is not being used for fertility purposes, the use of a barrier method of contraception (e.g., condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy throughout the course of treatment is recommended. Regular pregnancy tests every 4 weeks during the treatment are also advised. 

Parlodel may impact breast milk production, so breastfeeding is not recommended during its use. Consult with your doctor before making any decisions regarding breastfeeding.