Indications 

Orgalutran is an Injection medication used to prevent premature ovulation (early release of eggs from the ovary) during controlled ovarian stimulation in women undergoing fertility treatment.  

Orgalutran contains the active ingredient ganirelix. Ganirelix belongs to the class of medications known as gonadotropin-releasing hormone (GnRH) antagonists. It blocks the effects of gonadotropin-releasing hormone (GnRH). 

Use and Dosage 

Orgalutran Injection is available as a solution for injection in a pre-filled syringe. It can be self-administered at home if you have been properly trained by a healthcare professional. The usual dose is the contents of one pre-filled syringe of Orgalutran once a day on specific days of the menstrual cycle, as directed by a doctor.  

To use Orgalutran Injection, first, wash your hands thoroughly with soap and water. Next, prepare the injection site by cleaning it with an alcohol swab. Remove the protective cap from the pre-filled syringe and hold the syringe at a 45-degree angle to the skin. Pinch the skin at the injection site and insert the needle into the skin. Slowly inject the medication and remove the needle from the skin. Dispose of the syringe in a sharps container.  

Use the Injection exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible. If you are more than 6 hours late (the time between 2 injections is longer than 30 hours), give the dose as soon as possible and contact your doctor for further instruction. Do not inject a double dose to make up for a missed dose.  

Side Effects 

Common Side Effects  

• Abdominal pain 
• Dizziness 
• Feeling generally unwell 
• Headache 
• Hot flushes 
• Lack or loss of strength or energy 
• Nausea 
• Pain 
• Redness, swelling, or irritation at the place of injection 

Serious Side Effects 

• Abdominal pain or cramping 
• Cramping in the abdomen 
• Difficulty breathing 
• Fainting 
• Hives 
• Lightheadedness 
• Shoulder pain 
• Swelling of the face, throat, or tongue 
• Vaginal bleeding or spotting 
• Vaginal bleeding vaginal discharge of fluid or tissue 

Cautions 

• Orgalutran Injection is for subcutaneous use only.  
• The injection site should be changed every day to lessen possible injection site reactions.  
• Ganirelix acetate may interact with other medications, herbs, non-prescription drugs, or dietary supplements. Inform your healthcare provider of all medications you are taking. 
• Ganirelix acetate may cause side effects, which may not be limited to allergic reactions, injection site reactions, ovarian hyperstimulation syndrome (OHSS), and multiple pregnancies. 
• Ganirelix acetate is not recommended for use during pregnancy. Inform your healthcare provider if you are pregnant or planning to become pregnant. 
• Ganirelix acetate may pass into breast milk and may harm a nursing baby. Inform your healthcare provider if you are breastfeeding. 
• Ganirelix acetate may cause a decrease in bone mineral density. Women who are at risk of osteoporosis or have a history of osteoporosis should use it with caution. 
• In rare cases, ganirelix acetate may cause anaphylaxis, a severe allergic reaction. Seek immediate medical attention if you experience symptoms of anaphylaxis, such as difficulty breathing, swelling of the face, lips, tongue, or throat, and/or hives. 
• Ganirelix acetate may increase the risk of blood clots. Women with a history of blood clots or a high risk of blood clots should use Orgalutran with caution. 
• Ganirelix acetate may affect the results of certain laboratory tests, such as hormone tests. Inform your healthcare provider that you are using it if you need to have any laboratory tests done. 
• The safety and effectiveness of ganirelix acetate in children have not been established. IDo not use it for children. 
• Inform your healthcare provider of any medical conditions you have, especially liver or kidney disease, as it may affect the use of ganirelix acetate.