Indications 

The grass pollen allergenic extract falls within the category of pharmaceutical agents known as allergy immunotherapies. The primary purpose is ameliorating symptoms associated with moderate-to-severe seasonal allergies triggered by grass pollens, particularly in cases where conventional allergy interventions have proven ineffective. Before commencing treatment with grass pollen allergenic extract, a medical professional should establish the presence of the allergy through either cutaneous or serological testing. 

The mechanism of action for this medication entails the modulation of the body’s immune response, rendering it less susceptible to the adverse effects of pollen exposure. Administration of this therapy may be initiated at any juncture throughout the year; however, initiation approximately four months before the grass pollen season is advisable to yield optimal symptomatic relief during the initial allergy season. 

Uses and Dosage 

The dosing regimen for adults and children aged five years and older necessitates a gradual dosage escalation during the initial three days of treatment. On the first day of treatment, a dosage of 100 International Units (IR), dissolved sublingually, should be administered once daily. This is followed by an increase to 200 IR on the second day. The maintenance dosage, which initiates on the third day and persists after that, comprises 300 IR dissolved under the tongue once daily. 

Recognize that several variables can influence the appropriate dosage of this medication for an individual, encompassing factors such as body weight, concurrent medical conditions, and concomitant medications. If your physician has prescribed a dosage regimen distinct from the guidelines above, consult your healthcare provider before altering your administration pattern. 

Handle the tablet with dry hands to administer this medication, extracting it from the packaging immediately before use. Subsequently, place the tablet beneath the tongue and permit it to dissolve. Abstain from swallowing for 1 minute to facilitate transmucosal absorption. Following tablet ingestion, refrain from eating or drinking for 5 minutes, and exercise proper hand hygiene after handling the medication. 

Side Effects 

Common Side Effects

If you encounter any of the following side effects, and if they are severe or disruptive, promptly contact your healthcare provider for guidance. Alternatively, your pharmacist may offer insights into managing these side effects: 

• Allergy symptoms, such as:  
  • Runny or stuffy nose 
  • Itchy or watery eyes 
• Symptoms indicative of asthma include:  
  • Wheezing, difficulty breathing, or persistent cough 
• Cough 
• Diarrhea 
• Dizziness 
• Dryness in the mouth 
• Itchiness in the ears or eyes 
• Headache 
• Heartburn 
• Hives or generalized itching on the body 
• Tingling, itching, or swelling in the mouth 
• Nausea 
• Swelling of the tongue 
• Irritation in the throat 
• Feelings of fatigue 

Severe Side Effects

While most of the side effects mentioned above are infrequent, they could escalate into serious issues if left unaddressed. Consult your healthcare provider promptly if you experience any of the subsequent side effects: 

• Bleeding gums 
• A sensation of blockage in the ears 
• Discomfort or tightness in the chest 
• Enlargement of glands 
• A pervasive sensation of tingling or numbness 
• Nosebleeds 
• Abdominal pain 

Cautions 

Grass pollen allergen extract should not be administered under the following circumstances: 

• If you are allergic to this medication or any of the constituent ingredients. 
• In cases where a prior episode of severe allergic reaction to grass immunotherapy has occurred. 
• If you suffer from severe chronic or seasonal asthma. 
• When concurrently taking medications belonging to the beta-blocker family or angiotensin-converting enzyme inhibitor (ACEI) family. 
• In the presence of severe immune deficiency or an autoimmune disorder. 
• If you have been diagnosed with cancer. 
• In instances of oral sores, yeast infections, or other forms of inflammation within the oral cavity. 

Exercise caution and refrain from administering this medication to children below the age of 5 years.