Indications 

Ofev is a medication indicated for individuals with lung diseases that cause the development of scar tissue deep within the lungs, known as fibrosis. Over time, this scar tissue thickens and stiffens, making it more difficult for the lungs to function properly, resulting in reduced lung capacity and breathing difficulties. Moreover, inadequate oxygenation of other vital organs such as the brain and heart can cause additional medical complications. 

Ofev is prescribed for the treatment of idiopathic pulmonary fibrosis (IPF), a lung disease characterized by the buildup of scar tissue, as well as chronic interstitial lung disease in which the scar tissue continuously worsens.  

The medication is used to decelerate the decline in lung function in individuals with systemic sclerosis-associated interstitial lung disease, known as scleroderma-associated ILD. 

While Ofev is not a cure for IPF or ILD, it can help to slow down the progression of these diseases on the lungs. 

Uses and Dosage 

Before taking nintedanib, ensure to read the Patient Information Leaflet, which is available from your pharmacist. If you have any queries, feel free to ask your pharmacist or doctor for assistance. 

Take this medication orally with food, twice daily (with an interval of approximately 12 hours), as prescribed by your physician. The dosage depends on your medical condition and response to treatment. Adhere to your doctor’s instructions strictly. 

Do not crush or chew the capsules, as they have a bitter taste. Swallow them whole and avoid opening them. If the content of the capsules comes into contact with your skin, wash your hands immediately. 

To obtain the maximum benefit from this medication, use it regularly. To help you remember, take it at the same time every day. 

Side Effects 

Allergic Reactions  

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Call your doctor at once if you have: 

• Severe ongoing nausea, vomiting, or diarrhea 
• Severe stomach pain, bloating, or tenderness 
• Bleeding from your rectum or blood in your stools 
• Easy bruising or bleeding, any wound that will not heal 
• Fever, chills, cough with mucus, chest pain, feeling short of breath 
• Heart attack symptoms such as:
  • Chest pain or pressure
  • Pain spreading to your jaw or shoulder
  • Nausea
  • Sweating 
• Liver problems such as:
  • Stomach pain (upper right side)
  • Loss of appetite
  • Tiredness
  • Dark urine
  • Jaundice (yellowing of the skin or eyes) 
• Signs of a stroke such as: 
  • Sudden numbness or weakness (especially on one side of the body)
  • Slurred speech
  • Problems with vision or balance 

Liver problems may be more likely in: 

• Women 
• People who weigh less than 143 pounds (65 kilograms) 
• People of Asian descent 

Common Side Effects  

• Nausea, vomiting, loss of appetite 
• Stomach pain 
• Diarrhea, weight loss 
• Increased blood pressure 
• Headache 
• Abnormal liver function tests 

Caution 

Prior to taking nintedanib, inform your doctor or pharmacist about any allergies you may have or any other allergies to inactive ingredients that may cause allergic reactions or other issues. Kindly consult your pharmacist for additional information. 

Share your medical history with your doctor or pharmacist, especially if you have liver disease, heart disease such as chest pain or heart attack, high blood pressure, blood clots, bleeding problems, blood vessel problems such as an aneurysm or a tear/break in the aorta or other blood vessels, recent abdominal surgery, or stomach/intestinal problems such as ulcers or diverticular disease. 

Prior to undergoing surgery, inform your doctor or dentist of all the products you use, including prescription drugs, nonprescription drugs, and herbal products. 

If you are pregnant or plan to become pregnant, notify your doctor. Do not conceive while using nintedanib since it may be harmful to an unborn baby.  

Your doctor should perform a pregnancy test before beginning this medication. Inquire about dependable methods of birth control (such as condoms) when using this medication and for at least 3 months after stopping treatment. If you become pregnant, speak with your doctor immediately about the advantages and disadvantages of taking this medication.