Indications 

Nesina is a prescribed medication used alongside diet and exercise to enhance blood sugar control in adults with type 2 diabetes mellitus, a condition where blood sugar is too high due to the body’s impaired insulin production or utilization. 

Classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor, Nesina functions by elevating levels of incretins, which are natural substances that aid in regulating blood sugar. These incretins promote insulin release, particularly following meals, while reducing the liver’s sugar production. 

Uses and Dosage 

Before taking Nesina and with each prescription refill, carefully review its medication guide and patient information leaflet. Seek advice from your doctor or pharmacist if you have questions or concerns. 

The dosage of Nesina is determined based on the patient’s medical condition and response to the treatment.  

Typically, Nesina is taken once a day as prescribed by the doctor, without regard to food intake. 

To achieve the best outcome, adhere to a fixed daily schedule for taking this medication and diligently comply with a diabetes management regimen, including medications, diet, and exercise. 

Continue taking Nesina as prescribed, even if you are feeling well. Do not discontinue use without consulting your doctor. 

Side Effects 

Listed below are the potential adverse effects of Nesina. Inform your doctor promptly if any of them persist or worsen. 

Common Side Effects 

• Headache 
• Cold symptoms: 
  • Stuffy nose 
  • Sinus pain 
  • Sore throat 

Serious Side Effects 

• Severe or persistent joint pain 
• Signs of heart problems: 
  • Shortness of breath 
  • Rapid weight gain 
  • Swelling in the feet, legs, or midsection 
• Signs of liver issues: 
  • Nausea 
  • Upper stomach pain 
  • Fatigue 
  • Loss of appetite 
  • Dark urine 
  • Clay-colored stools 
  • Jaundice 
• Serious autoimmune reaction characterized by: 
  • Itching 
  • Blisters 
  • Skin layer breakdown 
• Signs of a severe skin reaction: 
  • Fever 
  • Sore throat 
  • Burning eyes 
  • Skin pain 
  • Red or purple skin rash with blistering and peeling 

Call your doctor immediately if any of the following severe side effects are experienced. 

Discontinue the use of Nesina immediately and promptly contact your doctor if you experience symptoms of pancreatitis such as: 

• Intense upper stomach pain that radiates to your back 
• Nausea 
• Vomiting 
• Loss of appetite 
• Rapid heartbeats 

Allergic Reactions 

Although rare, a severe allergic reaction to Nesina may occur. If any of the below symptoms occur, promptly seek medical assistance: 

• Rash 
• Severe dizziness 
• Itching or swelling of the face, tongue, or throat 
• Trouble breathing  

Not all side effects of Nesina are included in this list. In case of any unlisted effects, inform your doctor immediately. 

Cautions 

Nesina is contraindicated for patients diagnosed with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. 

Before starting treatment with Nesina, inform your doctor and pharmacist of any known allergies, particularly to alogliptin, other drugs, or any components contained in Nesina tablets. 

To ensure Nesina is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Kidney disease 
• Heart failure 
• Liver problems 
• Pancreatitis 
• Gallstones 

Inform your doctor and pharmacist of all prescription and non-prescription drugs, vitamins, and herbal supplements you are taking, as they may enhance or diminish the efficacy of Nesina in reducing blood sugar levels.  

Nesina should only be used if necessary during pregnancy due to the potential for diabetes complications. Consult with your doctor to develop a plan for controlling blood sugar levels during pregnancy, which may involve adjusting treatment methods like diet, exercise, and medication, including insulin. 

The transfer of alogliptin into breast milk is uncertain. Consult your doctor before breastfeeding while using this medication.