Indications 

Myfortic is a prescribed medication used to prevent organ rejection in adults who have received kidney transplants, as well as in children aged 5 years and older who are at least 6 months post-kidney transplant. 

This medication is typically given in combination with cyclosporine and corticosteroids. As an antimetabolite immunosuppressant, Myfortic functions by suppressing the body’s immune system, preventing it from attacking and rejecting the transplanted organ. 

Uses and Dosage 

Before starting treatment with Myfortic and with each prescription refill, carefully review its medication guide and patient information leaflet. Ask your doctor or pharmacist if you have questions or uncertainties. 

The dosage of Myfortic is determined based on the patient’s medical condition and response to treatment. For children, body size is also considered. 

Typically, Myfortic is taken twice daily on an empty stomach, either 1 hour before or 2 hours after eating. Tablets must be swallowed whole, not crushed, chewed, or cut. 

Take precautions to prevent contact with tablet dust. Avoid direct skin or eye contact. In case of contact, thoroughly wash the affected skin with soap and water or rinse the eyes with plain water. For further information, consult your pharmacist. 

For optimal results, administer this medication at consistent times each day, ideally with 12-hour intervals between doses. 

Take Myfortic exactly as directed. Do not alter the dosage and frequency of intake or discontinue this medication without consulting your doctor, even if you feel well. 

Side Effects 

Listed below are the potential adverse effects of Myfortic. Inform your doctor promptly if any of these symptoms last or worsen. 

Common Side Effects 

• Constipation 
• Nausea 
• Headache 
• Diarrhea 
• Vomiting 
• Stomach upset 
• Gas 
• Tremor 
• Dizziness 
• Drowsiness 
• Trouble sleeping 

Serious Side Effects 

Tell your doctor promptly if you experience any of the following: 

• Unusual tiredness 
• Fast/irregular heartbeat 
• Easy bleeding/bruising 
• Swelling of the feet or ankles 
• Joint pain/stiffness 
• Muscle pain 

Very severe side effects may also occur. Get immediate medical assistance if you experience any of the following:  

• Persistent stomach/abdominal pain 
• Black stools 
• Vomit resembling coffee grounds 
• Chest pain 
• Shortness of breath or rapid breathing 

Myfortic may elevate the risk of a rare but potentially life-threatening brain infection called progressive multifocal leukoencephalopathy (PML). Seek immediate medical assistance if you experience any of these symptoms: 

• Clumsiness 
• Loss of coordination or balance 
• Weakness 
• Sudden changes in thinking (e.g., confusion, difficulty concentrating, memory loss) 
• Difficulty talking or walking 
• Seizure 
• Vision change 

Allergic Reactions 

Although rare, a severe allergic reaction to Myfortic may occur. Seek urgent medical attention if any of the following symptoms arise: 

• Rash 
• Swelling or itching, particularly in the face, tongue, and throat 
• Severe dizziness 
• Trouble breathing 

This list does not contain all the potential side effects of Myfortic. If any unlisted effects occur, tell your doctor promptly. 

Cautions 

Before starting treatment with Myfortic, inform your doctor if you have any known hypersensitivities, especially to: 

• Mycophenolic acid 
• Mycophenolate mofetil 
• Other medications 
• Any ingredients present in Myfortic tablets and delayed-release tablets 

To ensure Myfortic is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Cancer 
• Liver disease (such as hepatitis B or hepatitis C) 
• Current or past infections (such as herpes or shingles) 
• Stomach or intestinal problems (such as ulcers) 
• Rare genetic disorders (such as Lesch-Nyhan or Kelley-Seegmiller syndromes) 

Myfortic may interact with other drugs, including those that weaken the immune system, like natalizumab and rituximab, increasing the risk of infection. Inform your doctor and pharmacist about all medications, vitamins, supplements, and herbal products you are currently or planning to use to avoid such interactions. 

To avoid hindering the absorption of Myfortic, refrain from taking antacids with aluminum or magnesium, cholestyramine, colestipol, or calcium-free phosphate binders (e.g., aluminum products, lanthanum, sevelamer) concurrently. For further information, consult your pharmacist. 

Myfortic increases susceptibility to infections and exacerbates existing ones. Avoid contact with individuals carrying easily transmissible infections (e.g., chickenpox, COVID-19, measles, flu). Consult your physician if exposed to an infection or for further information. 

Before receiving any immunizations or vaccinations, inform your healthcare provider that you are taking Myfortic. Steer clear of individuals who have recently been administered live vaccines, such as the nasal flu vaccine. 

Donating blood or sperm is prohibited while taking Myfortic and for a minimum of 6 weeks (blood) or 90 days (sperm) after the last dose. 

Myfortic may induce drowsiness, confusion, dizziness, lightheadedness, or tremors. Refrain from driving or operating machinery until you ascertain the impact of this medication on you. 

Myfortic increases sensitivity to sunlight. Take precautions such as wearing protective clothing and using sunscreen (SPF 30 or higher) when outside and avoid tanning beds. 

The use of Myfortic during pregnancy may result in miscarriage or congenital disabilities. Effective birth control is recommended for both genders during and after the treatment.  

Myfortic can reduce the effectiveness of hormonal birth control (pills, patches, or rings), leading to possible pregnancy. Use an additional non-hormonal form of birth control while taking this medication. Inform your doctor if you experience new spotting or breakthrough bleeding, as it could indicate that your birth control is ineffective. 

Due to the potential risk of harm to an unborn baby, women who are pregnant or planning to conceive should refrain from handling Myfortic or inhaling dust from the tablets, as the drug can be absorbed through the skin and lungs. 

Pregnant women may receive Myfortic despite its potential impact on fertility and pregnancy, particularly when other necessary transplant medications are not viable options. 

The transfer of mycophenolic acid to breast milk is uncertain. Due to potential harm to the baby, nursing while taking this medication is not advised. Seek advice from your physician before breastfeeding.