Indications 

Mepron is a prescribed medication indicated for the treatment of pneumocystis jirovecii, used to be called pneumocystis carinii (PCP), a type of pneumonia that primarily affects adolescents and adults with compromised immune systems. 

Mepron is also indicated for the prevention of PCP in adolescents and adults who cannot tolerate alternative prophylactic medications. 

As an antiprotozoal agent, Mepron halts the growth of select pneumonia-causing protozoa. By doing so, this medication alleviates infection symptoms, including fever, cough, fatigue, and shortness of breath. 

Uses and Dosage 

Before starting treatment with Mepron and with each prescription refill, carefully review its medication guide and patient information leaflet. Should you have any inquiries or clarifications, seek guidance from your doctor or pharmacist. 

Mepron comes as a liquid suspension that requires gentle shaking before use to ensure even medication distribution. Accurate dosing requires a measuring spoon or cup, not a household spoon. 

The usual dosing recommendations of Mepron are provided below; however, adhere to your doctor’s prescription if instructed differently: 

• For the prevention of PCP: Take 1,500 mg (10 mL) orally once daily with food. 
• For the treatment of PCP: Take 750 mg (5 mL) twice daily (total daily dose 1,500 mg) with food for 21 days. 

To ensure optimal efficacy, maintain a consistent level of this medication in your body. If prescribed to take it twice daily, administer doses at 12-hour intervals. If you take this medication once a day, take it consistently around the same time every day. 

Complete the full prescribed course of Mepron, even if symptoms improve within a few days. Prematurely discontinuing this medication may lead to a recurrence of the infection. 

Inform your doctor promptly if you develop symptoms of PCP or if your condition persists or deteriorates. 

Side Effects 

Listed below are the potential adverse effects of Mepron. Notify your physician if any of them persist or deteriorate. 

Common Side Effects 

• Nausea, vomiting, or diarrhea 
• Headache 
• Fever 
• Rash 

Serious Side Effects 

• Signs of liver problems: 
  • Loss of appetite 
  • Upper right stomach pain 
  • Fatigue 
  • Dark urine 
  • Jaundice (yellowing of skin or eyes) 
• Symptoms of severe skin reaction: 
  • Fever 
  • Sore throat 
  • Eye burning 
  • Skin pain 
  • Red or purple skin rash that spreads, blisters, and peels 

Call your doctor right away if you experience any of the severe side effects mentioned above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Mepron may occur. Get immediate medical assistance if you observe any of the following symptoms: 

• Hives 
• Difficult breathing 
• Face or throat swelling 

This list does not contain all the potential side effects of Mepron. If you experience any unlisted effects, inform your doctor without delay. 

Cautions 

Before starting treatment with Mepron, inform your doctor and pharmacist if you have any known hypersensitivities, especially to atovaquone, other medications, or to any ingredients present in Mepron suspension. 

To ensure Mepron is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Liver disease 
• Kidney disease 
• Stomach or intestinal issues that may impact atovaquone absorption (e.g., chronic diarrhea, malabsorption syndrome) 

Inform your doctor and pharmacist about all medications you use, including prescription/nonprescription drugs, vitamins, and herbal products, to lower the chance of drug interactions with Mepron. 

Certain medications can reduce the concentration of Mepron in the body, potentially affecting its effectiveness. Examples include: 

• Efavirenz 
• Metoclopramide 
• Rifampin 
• Rifabutin 
• Tetracycline 

Mepron can cause dizziness, which may intensify when combined with alcohol or marijuana. Limit your alcohol intake, consult your doctor if you use marijuana, and do not operate machinery or drive until you regain alertness.  

Mepron should only be used during pregnancy if necessary. Consult with your doctor to assess the potential risks and benefits. 

The transfer of atovaquone into breast milk is uncertain. Consult with your doctor before nursing an infant when taking this medication.