Indications 

Lutrepulse is used to induce ovulation in women diagnosed with primary hypothalamic amenorrhea, a condition characterized by absent menstrual periods caused by insufficient levels of gonadotropin-releasing hormone (GnRH). 

Lutrepulse is a synthetic protein that works similarly to the naturally occurring GnRH originating from the brain’s hypothalamus. It serves to supply the necessary GnRH for the development and release of mature eggs from the ovaries, facilitating ovulation. 

Uses and Dosage 

Lutrepulse can be administered subcutaneously or intravenously via an infusion pump by a healthcare professional. 

Your doctor will provide detailed guidance on preparation and usage instructions for self-administration at home. If you opt for the infusion pump, your doctor will instruct you on its proper usage and maintenance. 

Before initiating treatment and with each prescription refill, carefully review the medication guide and patient information leaflet for Lutrepulse. If you have any questions, do not hesitate to consult your doctor or pharmacist. 

The dosage of Lutrepulse varies for each individual, depending on their medical conditions and treatment response. Strictly follow the dosage prescribed by your doctor. 

When administering this medication subcutaneously, injection sites must be rotated as instructed by your doctor to minimize subcutaneous tissue injury. For intravenous administration, site rotation is not necessary unless directed by your doctor. 

To achieve the best outcomes, use Lutrepulse exactly as directed. If you forget a dose, do not take extra medication. Instead, consult your doctor for guidance. 

Side Effects 

Common Side Effects 

• Headache, nausea, and mild abdominal pain during menstrual bleeding 
• Mild irritation, redness, or bruising at the injection site 

Notify your doctor promptly if any of these common side effects persist or get worse. 

Serious Side Effects 

• Mental or mood changes (e.g., depression, mood swings, aggression) 
• Signs of infection: 
  • Persistent redness, pain, swelling, or warmth at the injection site that does not resolve 
  • Fever 
  • Chills 

Notify your doctor right away if you exhibit any of these serious side effects. 

Allergic Reactions 

Although rare, a severe allergic reaction to Lutrepulse can occur. Immediate medical assistance must be sought if any of the following symptoms manifest: 

• Face, lips, tongue, or throat swelling or itching 
• Rash 
• Severe dizziness 
• Trouble breathing 

This list does not include all potential side effects of Lutrepulse. Inform your doctor if you notice any effects not mentioned here. 

Cautions 

Before starting treatment with Lutrepulse, inform your doctor if you have any known allergies, particularly to gonadorelin or any inactive components present in this medication. 

To ensure Lutrepulse is safe for you, disclose to your doctor your medical background, especially if you have a history of: 

• Ovarian cysts 
• Kidney disease 
• Pituitary gland tumors (e.g., prolactinoma) 
• Reproductive organ cancers (ovary, breast, uterus) 
• Mental or mood issues like depression 

Medications that induce ovulation may interact with Lutrepulse. To mitigate these interactions, inform your doctor about all your recent and current medication usage, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. 

Lutrepulse use may lead to ovarian hyperstimulation syndrome (OHSS), where excessive follicle growth can result in symptoms like abdominal or pelvic pain, nausea, vomiting, weight gain, breathing difficulty, and diarrhea. Contact your doctor immediately if you experience any of these symptoms, as OHSS can progress rapidly and become severe. 

Consult your doctor before using Lutrepulse if you are pregnant, as it should only be employed during pregnancy as part of fertility treatment. Discuss the possibility of multiple births with your doctor before starting Lutrepulse treatment.  

Consult your doctor before using Lutrepulse if you are breastfeeding, as it is uncertain whether gonadorelin passes into breast milk.