Drug Description:

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The manufacturer of Latuda is Servier Laboratories and Sunovion Pharmaceutical.

Indications

Latuda is an antipsychotic medication for the treatment of:

• Schizophrenia in adults and adolescents (13 to 17 years of age)
• Depressive episode associated with Bipolar I Disorder (bipolar depression) in adults and pediatric patients (10 to 17 years of age) as monotherapy
• Depressive episode associated with Bipolar I Disorder (bipolar depression) in adults as combination therapy with lithium or valproate

Latuda, which is classified as an atypical or second-generation antipsychotic, helps rebalance certain chemicals (dopamine and serotonin) in the brain to help reduce symptoms of schizophrenia and bipolar depression. Bipolar depression is the “low” or depressed phase of bipolar disorder

Dosage and Administration

It is important to take Latuda exactly as your healthcare provider prescribes and you should not change the dose yourself.

The following table outlines the starting and recommended doses of Latuda according to indication and age:

• Latuda tablets should be taken with food (at least 350 calories)
• Latuda tablets should be swallowed whole and should not be cut or split

Side Effects

The most common side effects associated with Latuda include:

Adults with Schizophrenia

• Sleepiness or drowsiness
• Restlessness and an intense, uncontrollable need to move (akathisia)
• Difficulty moving, slow movements, muscle stiffness, or tremor
• Nausea

Adolescents with Schizophrenia

• Sleepiness or drowsiness
• Nausea
• Restlessness and an intense, uncontrollable need to move (akathisia)
• Difficulty moving, slow movements, muscle stiffness, or tremor
• Runny nose
• Vomiting

Adults with Bipolar Depression

• Restlessness and an intense uncontrollable need to move (akathisia)
• Difficulty moving, slow movements, muscle stiffness, or tremor
• Sleepiness or drowsiness

Pediatric Patients with Bipolar Depression

• Nausea
• Weight gain
• Problems sleeping (insomnia)

Serious Side Effects

Certain serious adverse effects may occur while taking Latuda. Stop taking Latuda and contact your healthcare provider if you develop any of the following symptoms:

• Stroke in elderly people with dementia-related psychosis that can lead to death
• Neuroleptic malignant syndrome (NMS), a serious condition that can lead to death Contact your healthcare provider or go to the nearest emergency immediately if you experience any of the following:
  • High fever
  • Stiff muscles
  • Confusion
  • Increased sweating
  • Changes in your breathing, heart rate, or blood pressure
• Uncontrolled body movements (tardive dyskinesia)
• Problems with metabolism, including:
  • High blood sugar (hyperglycemia) and diabetes

Call your healthcare provider if you experience any of the following:

• Increased thirst
• Need to urinate more than usual
• Increased hunger
• Weakness or tiredness
• Upset stomach
• Confusion
• Fruity breath
  • Increased cholesterol and triglyceride levels
  • Weight gain
• Increased prolactin levels in your blood

Females:

• Absence of menstrual cycle
• Secretion of breast milk when not breastfeeding

Males:

• Problems getting/maintaining an erection (erectile dysfunction)
• Enlargement of breasts (gynecomastia)
• Low white blood cell count
• Decreased blood pressure
• Falls
• Seizures
• Problems regulating your body temperature so that you feel too warm
• Mania or manic episodes (greatly increased energy, severe insomnia, racing thoughts, reckless behavior, excessive happiness or irritability, talking more or faster than usual)
• Difficulty swallowing

Allergic Reactions

Do not take Latuda if you are allergic to lurasidone or any of the tablet ingredients. If you develop an allergic reaction, stop using this antipsychotic medication and contact your healthcare provider.

Warnings and Precautions

Elderly persons with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death and should not take Latuda.

There is an increased risk of suicidal thoughts and behavior in pediatric and young adult patients taking antidepressants.  These persons should be closely monitored for clinical worsening and emergence of suicidal thoughts and behaviors.

Latuda may make you drowsy, and you should not drive, operate heavy machinery, or do other dangerous activities until you know how Latuda affects you.

Avoid eating grapefruit or drinking grapefruit juice during treatment with Latuda because grapefruit and grapefruit juice may affect the amount of Latuda in your blood.

Do not become too hot or dehydrated during treatment with Latuda.

• Do not exercise excessively
• In hot weather, stay inside in a cool place if possible
• Stay out of the sun
• Do not wear heavy clothing
• Drink plenty of water

Before taking Latuda, tell your healthcare provider if you have ever had any of the following:

• Heart problems or stroke
• High or low blood pressure
• Diabetes or high blood sugar, or a family history of diabetes or high blood sugar
• High levels of cholesterol or triglycerides
• High prolactin levels
• Low white blood cell count
• Seizures
• Kidney or liver problems
• If you are pregnant or plan to become pregnant (unclear if lurasidone will cause harm to an unborn baby)
• If you are breastfeeding or plan to breastfeed (unclear if lurasidone passes into breastmilk and will harm a nursing child)

Some drugs may interact with Latuda and cause unwanted effects. Be sure to tell your healthcare provider about all the medications you take, including over- the-counter medications, and any of the following:

• Ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil
• Diltiazem, atazanavir, erythromycin, fluconazole, verapamil
• Rifampin, avasimibe, St. John’s wort, phenytoin, carbamazepine
• Bosentan, efavirenz, etravirine, modafinil, nafcillin

Latuda Form and Strengths

This antipsychotic medication is available in film-coated tablet form.

Latuda tablet strengths:

• 20mg
• 40mg
• 60mg
• 80mg
• 120mg

All tablet strengths are available in bottles of 30, 90, and 500 tablets and boxes of 100 (10 blister cards/10 tablets each).

FAQs

How long will it take before Latuda will start to work?

Individual response to this medication will vary. You should talk with your healthcare provider to discuss this.

Can I chew, split, or crush Latuda?

Latuda tablets should be swallowed whole and should never be chewed, split, or crushed.

Why do I need to take Latuda with at least 350 calories of food?

Taking Latuda with food helps this drug stay in your system long enough for your body to absorb the full dose.

Resources:

1. https://www.latuda.com/bpd/about-latuda.html
2. https://www.latuda.com/LatudaPrescribingInformation.pdf