Indications 

Fosamax is a prescription medication indicated for preventing and treating certain types of osteoporosis in adults, a condition in which the bones become brittle, thin, and fragile, rendering them susceptible to fractures. 

Fosamax is used explicitly for: 

• Treating and preventing osteoporosis in postmenopausal women 
• Increasing bone mass in men with osteoporosis 
• Treating glucocorticoid-induced osteoporosis  
• Treating Paget’s disease of bone  

As a bisphosphonate medication, Fosamax impedes osteoclast activity, which is responsible for bone resorption. By reducing bone loss, this medication enhances bone density and promotes osteoblast function, leading to stronger bones. 

Uses and Dosage 

Before taking Fosamax and with each refill, carefully review the patient information leaflet and medication guide. Adhere closely to the instructions of intake to maximize drug absorption and minimize the risk of esophageal injury. Seek guidance from your doctor or pharmacist if needed. 

Fosamax dosage and length of intake may vary based on the condition being treated and the response to the treatment. Typically, it is taken once a day as directed by the doctor, on an empty stomach immediately after waking up, before consuming any food or drink. 

Swallow Fosamax tablet whole with a full glass (6-8 ounces or 180-240 milliliters) of plain water; do not chew or suck on it.  

After taking Fosamax, abstain from eating, drinking, or taking any other medications or vitamins for a minimum of 30 minutes. Avoid lying down for 30 minutes; instead, sit or stand upright until you have consumed your first meal of the day. 

Comply strictly with the prescribed instructions for Fosamax administration. Never ingest it before waking up or at bedtime, as it may lead to inadequate absorption and side effects. 

Fosamax is only a component of a comprehensive treatment plan that may require dietary modifications, physical activity, bone mineral density monitoring, and calcium and vitamin supplements. Refrain from modifying the dose or frequency of administration and adhere to the prescribed regimen. 

For optimal benefits, take Fosamax at the same time(s) daily and regularly evaluate with your doctor whether Fosamax therapy is still necessary. 

Fosamax effectively controls osteoporosis and Paget’s disease of bone, but it is not a cure for these conditions. Continue to take this medication even if you feel well, for an increase in bone density may take at least three months. Seek medical advice before stopping treatment.  

Side Effects 

Potential adverse reactions associated with the use of Fosamax are listed below. If any of them last or worsen, inform your physician promptly. 

Common Side Effects 

• Heartburn or upset stomach 
• Stomach pain or nausea 
• Diarrhea or constipation 
• Headaches 
• Bone pain, muscle, or joint pain 

Serious Side Effects 

• Chest pain, exacerbation of heartburn 
• Difficulty or painful swallowing 
• Pain or burning sensation under the ribs or in the back 
• Severe heartburn, burning pain in the upper abdomen or coughing up blood 
• New or unusual pain in the thigh, hip, or groin 
• Jaw pain, numbness, or swelling 
• Severe joint, bone, or muscle pain 
• Symptoms of low calcium levels  
• Muscle spasms or contractions 
• Numbness or tingling sensations (around the mouth or in the fingers and toes) 

Call your doctor immediately if any of the severe symptoms listed above are experienced. 

Allergic Reactions 

Prompt medical attention should be sought if any signs of an allergic reaction to Fosamax are observed, such as: 

• Rash 
• Difficult breathing 
• Severe dizziness 
• Facial, lips, tongue, or throat itching or swelling 

The adverse effects of Fosamax listed here are not exhaustive. Inform your doctor immediately if any unmentioned side effects occur and cause discomfort. 

Cautions 

Before starting treatment with Fosamax, inform your healthcare provider or pharmacist if you have any known hypersensitivity, especially to alendronate, other medications, or to other ingredients present in Fosamax. 

To ensure Fosamax is safe for you, disclose to your doctor your medical history, particularly of: 

• Esophageal disorders (such as esophageal stricture or achalasia) 
• Difficulty swallowing 
• Incapacity to maintain an upright standing or sitting position for a minimum of 30 minutes 
• Low calcium levels 
• Kidney problems 
• Stomach/intestinal disorders (such as ulcers) 

To avoid potential drug interactions, disclose all current or planned prescription and non-prescription medications, dietary supplements, vitamins, and herbal products to your doctor and pharmacist before taking Fosamax. 

The absorption of Fosamax may be reduced by various substances such as: 

• Calcium or iron supplements 
• Vitamins 
• Antacids 
• Coffee, tea, soda, and mineral water 
• Calcium-enriched juices and foods 

To ensure proper absorption, wait at least 30 minutes (preferably 1 to 2 hours) after taking Fosamax before consuming any of the above-said substances. 

Fosamax may result in severe stomach or esophagus complications. If you encounter chest pain, new or aggravated heartburn, or painful swallowing, discontinue using this medication and promptly contact your doctor. 

This medication may also lead to jawbone loss (osteonecrosis) or femur fracture in rare instances. Inform your doctor promptly of signs of osteonecrosis, including numbness or jaw pain, swollen or red gums, loose teeth, or delayed dental healing. And symptoms of femur fracture such as leg or groin discomfort. 

The effect of Fosamax on a fetus is uncertain. Inform your doctor if you are pregnant or intend to conceive. Discontinue this medication and promptly notify your doctor if you become pregnant. 

The excretion of alendronate in human milk is uncertain. Consult your doctor before nursing an infant while taking this medication.