Indications 

Exjade (Deferasirox) is indicated for treating persistent hyperferritinemia resulting from repeated blood transfusions. Exjade is employed in individuals with a specific blood disorder, namely non-transfusion-dependent thalassemia, who do not necessitate blood transfusions. Its mechanism of action involves the sequestration of iron, facilitating the elimination of excess iron through fecal excretion. Deferasirox is categorized as an iron-chelating agent within the pharmacological class.  

Certain blood disorders, such as sickle cell disease and anemia, often require frequent blood transfusions, which provide substantial benefits. However, these transfusions can contribute to excessive iron accumulation within the body. Iron overload can lead to complications like heart failure, liver disease, and diabetes. Reducing excess iron levels can mitigate the risk of developing these conditions. 

Uses and Dosage 

Exjade removes excess iron from the bloodstream. This medication treats iron overload caused by blood transfusions in adults and children (2 years and older). It can treat chronic iron overload syndrome due to a genetic blood disorder (non-transfusion-dependent thalassemia) in adults and children (10 years and older). 

Various factors, including your specific medical condition, body weight, results from laboratory tests, and your response to treatment, determine the prescribed dosage of this medication. Adjustments to your dosage may be necessary, or in some cases, the medicine may need to be discontinued altogether if you experience specific side effects. 

The administration of Exjade therapy is warranted exclusively in cases where patients exhibit clear indications of chronic transfusional iron overload. These indications should encompass the transfusion of a minimum of 100 mL/kg of packed red blood cells (equivalent to at least 20 units of packed red blood cells for an individual weighing 40 kg or more) alongside a consistently elevated serum ferritin level exceeding 1,000 mcg/L. 

Side Effects 

Some common side effects of this medication include:  

• Nausea 
• Vomiting 
• Diarrhea 
• Dizziness 

If these side effects persist or worsen, inform your doctor or pharmacist. 

Remember that your doctor has prescribed this medication because they have determined that the benefits outweigh the potential risks of side effects. Many individuals who use this medication do not experience severe side effects. 

However, if you encounter severe side effects, such as hearing loss or vision changes (such as blurred vision), notify your doctor immediately. 

Cautions 

Before initiating deferasirox treatment, inform your doctor or pharmacist about any known allergies, including allergies to deferasirox or other substances. This product may contain inactive ingredients that trigger allergic reactions or other complications. To obtain more comprehensive information, consult your pharmacist. 

Furthermore, disclose your medical history to your doctor or pharmacist, particularly if you have a history of kidney disease, liver disease, low platelet counts, advanced cancer, or certain bone marrow disorders characterized by impaired blood-forming cells (high-risk myelodysplastic syndromes). Providing this information allows healthcare professionals to make informed decisions regarding the appropriate medication use.