Indications 

Adapalene is a medication used to treat acne by reducing the number and severity of acne and promoting the healing of existing pimples. It belongs to a class of drugs called retinoids, which work by influencing cell growth, reducing swelling, and alleviating inflammation. 

Uses and Dosage 

Instructions for the application of Differin Cream: 

1. Apply Differin Cream to the affected areas of acne once daily, preferably before going to bed, and after washing the skin. 
2. Use a thin layer of the cream to avoid the eye and lip areas (refer to Precautions). 
3. Before applying the cream, make sure that the acne-affected areas are dry. 
4. In cases where this drug is necessary to reduce the frequency of application or temporarily discontinue treatment, the frequency of application can be resumed or therapy can be restarted once the patient can tolerate the treatment again. 
5. If patients use cosmetics, you must choose non-comedogenic and non-astringent products. 
6. Please note that the safety and effectiveness of Differin Cream have not been studied in neonates and young children. 

Side Effects 

Common Side Effects

Some common side effects of using this medication may include a brief sensation of warmth or stinging after application. 

During the first 2-4 weeks of using the medication, you may experience:  

• Skin redness 
• Dryness 
• Itching 
• Scaling 
• Mild burning 
• Temporary worsening of acne 

These effects typically diminish with continued use, but if they persist or worsen, inform your doctor or pharmacist promptly. Your doctor may adjust the frequency of use, change the strength of the medication, or recommend discontinuing it based on your individual response. 

Severe Side Effects

Serious side effects are rare, but notify your doctor immediately if you experience:  

• Very red/irritated skin 
• Intense burning sensation 
• Eye redness and watering 
• Eyelid swelling 
• Skin discoloration 

If you notice any symptoms of a serious allergic reaction, such as rash, itching/swelling (particularly of the face/tongue/throat), severe dizziness, or difficulty breathing, seek immediate medical assistance. 

Cautions 

In the event of a reaction indicating sensitivity or severe irritation, the use of the medication should be discontinued. If the level of local irritation warrants, patients should be advised to reduce the frequency of medication application, temporarily discontinue its use, or discontinue its use altogether.  

Prevent Differin Cream from coming into contact with the eyes, mouth, nasal angles, or mucous membranes. If the product accidentally enters the eye, immediate rinsing with warm water is recommended. The application of the product should be avoided on broken or eczematous skin, and it should not be used in patients with severe acne. 

Effects on driving and the use of machinery: Based on the pharmacodynamic profile and clinical experience, this drug is not expected to have an impact on the ability to drive or operate machinery.