Indications 

DDAVP is a prescription medication used to treat symptoms of diabetes insipidus, a condition that affects the regulation of fluid balance in the body characterized by excessive thirst and the production of large amounts of dilute urine. 

DDAVP is also indicated to help manage primary nocturnal enuresis (bed wetting) in patients aged 6 years and older. It can also be used to evaluate the capacity of the kidney to concentrate urine, (Renal Concentration Capacity Test) in pediatric patients aged 3 years and older. 

As an antidiuretic hormone, DDAVP works by acting as a substitute for vasopressin, a naturally occurring hormone in the body to help balance the amount of water and salt. 

Uses and Dosage 

Before starting treatment with DDAVP and with each subsequent refill, ensure to read its patient information leaflet and medication guide. Consult a healthcare professional for any questions or clarifications. 

The dosage of DDAVP may vary per individual based on the medical condition being treated and the response to the treatment. 

Administered orally, DDAVP is commonly prescribed to be taken two to three times per day for diabetes insipidus treatment and once daily at bedtime for nocturnal enuresis. 

Strictly adhere to the prescribed dosage regimen of DDAVP. Avoid taking more or less than what has been prescribed, and do not exceed the frequency specified by your physician. 

For optimal efficacy, take DDAVP regularly around the same time every day. Do not stop intake without consulting your doctor to avoid worsening conditions. 

Side Effects 

Listed below are the potential adverse reactions associated with DDAVP. If any of them persist or worsen, notify your physician or pharmacist promptly. 

Common Side Effects 

• Headache 
• Dizziness 
• Dry mouth 
• Nausea 
• Mild stomach pain 

Serious Side Effects  

• Signs of inadequate sodium levels in the body : 
  • Headache 
  • Confusion 
  • Hallucinations 
  • Muscle cramps 
  • Severe weakness 
  • Vomiting 
  • Loss of coordination 
  • Restlessness or unsteadiness 
• Sudden warmth, redness, or a tingly sensation (flushing) 
• Swelling or weight gain 
• Seizure 
• Weak or shallow breathing 
• Feeling light-headed with a risk of fainting. 

Older adults may be at a higher risk of experiencing the above-stated severe side effects. Get immediate medical assistance if any of them occur. 

Allergic Reactions 

Severe allergic response to DDAVP is rare. However, get immediate medical assistance if you notice any indications of an allergic reaction, such as: 

• Hives 
• swelling (especially of the face/lips/tongue/throat) 
• Severe dizziness 
• Difficulty breathing  

This list does not provide an exhaustive account of potential side effects associated with DDAVP. Should you encounter any unlisted effects, promptly seek advice from your physician or pharmacist. 

Cautions 

Prior to initiating treatment with DDAVP, inform your healthcare provider or pharmacist if you have a known hypersensitivity, especially to desmopressin or any of its inactive ingredients. Consult your pharmacist for additional information. 

Disclose your medical history to your doctor with specific emphasis on: 

• Kidney disease 
• High blood pressure 
• Heart issues (such as blocked blood vessels, and heart failure) 
• Conditions that could heighten your chances of fluid/mineral imbalances (such as cystic fibrosis) 
• Tendency to drink excessive water without being thirsty 
• Insufficient concentration of sodium in the bloodstream, commonly referred to as hyponatremia 
• Bleeding or clotting disorders 

Some products can potentially interact with DDAVP such as Tolvaptan and “Water pills” or diuretics (such as furosemide).  

To avoid potential drug interactions, inform your doctor about all other medications you are taking, including prescription/nonprescription drugs, supplements, and herbal products.  

Patients taking DDAVP, particularly children and older adults, should restrict their intake of water and other fluids. Taking too many fluids may lead to a serious, life-threatening electrolyte imbalance. Seek specific instructions from your doctor. 

If you observe that you are consuming more fluids than recommended, notify your doctor immediately as a modification to your treatment may be required. 

Pregnant women should only take DDAVP when necessary and after careful evaluation of the potential risks and benefits, in consultation with a physician. 

Desmopressin is present in small amounts in human milk, however, there is no information on its effect on the breastfed infant or milk production. Consult your doctor before nursing an infant while taking this medication.