Indications 

Oxaprozin is a pharmacological agent utilized in the treatment of arthritis, effectively alleviating pain, reducing swelling, and mitigating joint stiffness. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). 

For individuals managing a chronic condition such as arthritis, consult with a healthcare professional regarding the potential incorporation of non-drug treatments or alternative medication options to address pain management. Refer to the Warning section for further guidance and precautionary information. 

Uses and Dosage 

Prior to initiating the use of oxaprozin, carefully review the Medication Guide provided by your pharmacist. Read the guide each time you receive a refill of the medication. Should you have any inquiries, kindly consult your doctor or pharmacist for clarification and guidance. 

Administer this medication orally in accordance with the instructions provided by your doctor, typically once daily. Consume a full glass of water (8 ounces/240 milliliters) alongside the medication, unless otherwise instructed by your doctor. Refrain from lying down for a minimum of 10 minutes after taking this drug.  

If you experience stomach upset while using this medication, take it with food, milk, or an antacid. 

The dosage of oxaprozin is determined based on your specific medical condition, body weight, and response to treatment. As per the manufacturer’s recommendation, the daily dosage for adults should not exceed 1,800 milligrams or 26 milligrams per kilogram, whichever is lower.  

To minimize the potential risks of side effects, such as stomach bleeding, utilize this medication at the lowest effective dose for the shortest duration feasible. Refrain from increasing your dosage or taking the drug more frequently than directed.  

For chronic conditions like arthritis, continue adhering to the prescribed regimen as instructed by your doctor. Discuss the potential risks and benefits with your doctor or pharmacist. 

In certain conditions, such as arthritis, it may take up to 2 weeks of regular usage before experiencing the full therapeutic benefits of this drug. 

Side Effects 

In case of the following signs, seek immediate medical assistance: 

Allergic Reaction 

• Hives 
• Sneezing 
• Runny or stuffy nose 
• Wheezing or difficulty breathing 
• Swelling in the face or throat 

Severe Side Effects

Severe skin reaction: 

• Fever 
• Sore throat 
• Burning eyes 
• Skin pain 
• Red or purple skin rash with blistering and peeling 

For signs of a heart attack or stroke, promptly seek emergency medical help: 

• Chest pain spreading to the jaw or shoulder 
• Sudden numbness or weakness on one side of the body 
• Slurred speech 
• Shortness of breath 

Discontinue the use of Daypro and contact your doctor immediately if you experience the following: 

Skin-related: 

• Any degree of skin rash, regardless of severity 

Heart problems: 

• Swelling 
• Rapid weight gain 
• Shortness of breath 

Stomach bleeding: 

• Bloody or tarry stools 
• Coughing up blood or vomit resembling coffee grounds 

Liver problems: 

• Nausea 
• Upper stomach pain 
• Itching 
• Fatigue 
• Flu-like symptoms 
• Loss of appetite 
• Dark urine 
• Clay-colored stools 
• Jaundice (yellowing of the skin or eyes) 

Kidney problems: 

• Decreased or absent urination 
• Swelling in the feet or ankles 
• Fatigue or shortness of breath 

Low red blood cells (anemia): 

• Pale skin 
• Unusual tiredness 
• Feeling light-headed or short of breath 
• Cold hands and feet 

Common Side Effects  

• Nausea 
• Upset stomach 
• Diarrhea 
• Constipation 
• Rash 

Cautions 

Oxaprozin carries certain risks and precautions that should be considered: 

Cardiovascular risk: 

• Oxaprozin increases the risk of fatal heart attack or stroke, even in individuals without pre-existing risk factors. 
• Avoid using this medication immediately before or after undergoing heart bypass surgery (coronary artery bypass graft, or CABG). 

Gastrointestinal risk: 

• Oxaprozin may lead to stomach or intestinal bleeding, which can be life-threatening. 
• These complications can arise without warning, particularly among older adults. 

Do not use oxaprozin if: 

• You are allergic to it. 
• You have active bleeding in your stomach or intestines. 
• You have a history of asthma attacks or severe allergic reactions following the use of aspirin or other NSAIDs. 

Inform your doctor about your medical history, specifically: 

• Heart disease, high blood pressure, high cholesterol, diabetes, or smoking habits. 
• Previous heart attack, stroke, or blood clot. 
• Stomach ulcers or bleeding. 
• Asthma. 
• Liver or kidney disease. 
• Fluid retention. 

Pregnancy considerations: 

• Avoid taking oxaprozin during pregnancy unless explicitly advised by your doctor. 
• The use of NSAIDs during the final 20 weeks of pregnancy may cause serious heart or kidney problems in the unborn baby, as well as complications with the pregnancy. 

Breastfeeding: 

• Consult your doctor regarding the safety of breastfeeding while using oxaprozin. 

Age restrictions: 

• Oxaprozin is not approved for individuals below 6 years old.