Indications 

Arimidex is a medication prescribed for the treatment of breast cancer in postmenopausal women.  

Its mechanism of action involves the reduction of estrogen levels, thereby impeding the proliferation of certain estrogen-dependent breast tumors.  

Arimidex is administered to patients whose cancer has progressed despite prior treatment with tamoxifen (Nolvadex, Soltamox). 

Uses and Dosage 

Before initiating anastrozole therapy and with each subsequent refill. In case of any uncertainties, please seek guidance from your healthcare provider or pharmacist. 

The medication should be taken orally, as directed by your physician, usually once a day, with or without food. To maximize the therapeutic benefits, adhere to a regular dosing schedule, taking it at the same time each day. 

To avoid unwanted side effects, do not increase the dose or duration of treatment beyond the prescribed regimen. Doing so will not hasten symptom relief and may increase the risk of severe adverse reactions. 

As this medication can be absorbed through the lungs and skin and pose a potential hazard to an unborn baby, pregnant women or those who may conceive should avoid handling this drug or inhaling the tablet dust. 

Side Effects 

Allergic Reactions

• Hives, difficulty breathing, or swelling in your face or throat  
• Severe skin reaction, such as:
  • Fever
  • Sore throat
  • Burning eyes
  • Skin pain
  • Red or purple skin rash with blistering and peeling 

Serious Side Effects 

• Symptoms of bone fracture, including:
  • Bruising
  • Swelling
  • Tenderness
  • Pain that worsens with movement.
• Numbness, prickly feeling, pain, or weakness in your hands or wrists 
• Symptoms of liver problems, such as:
  • Right-sided upper stomach pain
  • Yellowing of your skin or eyes
  • General malaise 
• Symptoms of a stroke, such as:
  • Sudden numbness or weakness (especially on one side of the body)
  • Severe headache
  • Slurred speech
  • Problems with vision or balance 

Cardiac and Pulmonary Symptoms: 

• New or worsening chest pain
• Shortness of breath (even with mild exertion)
• Feel short of breath

Anastrozole may decrease blood flow to your heart, particularly if you have a history of coronary artery disease. 

Common Side Effects 

• Numbness, tingling, or tickling sensation in the skin
• Hot flashes
• Weakness
• Joint pain or stiffness
• Bone pain
• Risk of fracture
• Swelling in the arms, legs, or feet
• Sore throat
• Cough
• Shortness of breath
• Headache
• Back pain
• Depression
• Sleep problems (insomnia)
• High blood pressure
• Nausea
• Vomiting
• Rash  

Caution 

Prior to taking this oral medication, disclose your complete medical history to your physician, including any history of osteoporosis, heart disease, blood clots, high blood pressure or hypertension, and liver disease, as certain conditions may significantly affect your response to treatment. Discuss all prescription drugs, non-prescription drugs, supplements, and herbal products you are taking due to potential drug interactions. 

When taking this prescription drug, be vigilant for signs of a severe allergic reaction. Do not take this anti-cancer agent if you have a known allergy to anastrozole or any inactive ingredients in each tablet.  

If you experience symptoms of severe hypersensitivity, including difficulty breathing, severe dizziness, swelling, hives, or skin rashes, discontinue use of the medication and seek emergency medical treatment immediately. 

It should be noted that this medication can be absorbed through the skin and lungs, and caution should be exercised when handling it. Pregnant women and those who may become pregnant should not handle or inhale the powder of this medication due to the potential harm it may cause to unborn babies. 

While taking this aromatase inhibitor, avoid drinking alcohol as it may trigger or worsen side effects such as dizziness and vision changes. Safety precautions should be taken when engaging in activities that require alertness and clear vision, such as using machinery, driving, and cycling. 

This type of medication is contraindicated for pregnant and breastfeeding women due to potential risks. Remember that potential benefits should always be weighed against potential risks when considering treatment options.