Indications 

Anusol HC Suppository is a prescribed medication for treating inflamed hemorrhoids (enlarged veins in the lowest part of the rectum and anus) and post-irradiation (factitial) proctitis (damage or injury to the rectum due to radiation therapy). 

Anusol HC Suppository is also prescribed as an adjunct treatment for chronic ulcerative colitis (chronic inflammation of the colon and rectum), cryptitis (inflammation of intestinal glands), other inflammatory conditions of the anorectum, and pruritus ani (itchy sensation around the anus). 

Belonging to the class of drugs called corticosteroids, Anusol HC Suppository works by directly reducing inflammation in the rectum and anus, thus providing relief from rectal pain, itching, bloody diarrhea, and bleeding. 

Uses and Dosage 

Before using Anusol HC Suppository and with each prescription refill, thoroughly read its medication guide and patient information leaflet. If you have any questions or clarifications, do not hesitate to consult your doctor or pharmacist for guidance. 

The dosage and duration of Anusol HC Suppository treatment are determined by the patient’s medical condition and response to therapy. Usually, it is administered in the rectum 2 or 3 times daily as directed by a physician. 

To properly administer Anusol HC Suppository, follow these steps: 

1. Unwrap the suppository (minimize handling of the suppository as it is formulated to melt at body temperature) 
2. Optionally, moisten the tip with a few drops of water 
3. Lie on your left side and bend your right knee 
4. Insert the suppository gently into the rectum with your finger, pointed end first, deep enough to prevent it from slipping out 
5. Stay lying down for a few minutes 
6. Refrain from having a bowel movement for at least an hour to allow the medication to work 
7. Wash your hands thoroughly after each use 
8. Take precautions as staining of fabric may occur with the use of this suppository 

For optimal results, use Anusol HC Suppository regularly as directed. Avoid using excessive amounts or frequency beyond the prescribed duration, as it will not expedite improvement and may increase the risk of side effects. 

Consult your doctor before discontinuing long-term use of Anusol HC Suppository, as sudden cessation may exacerbate certain conditions. Your doctor may need to gradually reduce your dosage to mitigate any potential worsening of symptoms. 

Side Effects 

Listed below are the side effects associated with the use of Anusol HC Suppository. If any of these side effects last or worsen, notify your doctor right away. 

Common Side Effects 

• Stinging 
• Dryness 
• Burning 
• Tingling 

Serious Side Effects 

• Signs of high blood sugar:  
  • Confusion 
  • Increased thirst and hunger 
  • Frequent urination 
  • Flushing 
  • Fast breathing 
  • Fruity breath 
• Signs of weak adrenal gland:  
  • Severe upset stomach or vomiting 
  • Dizziness 
  • Muscle weakness 
  • Fatigue 
  • Mood changes 
  • Weight loss 
• Signs of Cushing’s disease: 
  • Upper back or belly weight gain 
  • Moon face 
  • Severe headache 
  • Slow healing 
• Change in eyesight 
• Severe headache 
• Irritation at the application site 
• Severe rectal bleeding or pain 

Tell your doctor right away if you experience any of the serious symptoms listed above. 

Allergic Reactions 

Seek emergency medical attention immediately if you exhibit signs of an allergic reaction to Anusol HC Suppository, including: 

• Rash 
• Hives 
• Itching 
• Red, swollen, blistered, or peeling skin with or without fever 
• Wheezing 
• Tightness in the chest or throat 
• Trouble breathing, swallowing, or talking 
• Unusual hoarseness 

• Mouth, face, lips, tongue, or throat swelling 

This list does not contain all the potential side effects of Anusol HC Suppository. If you notice other effects not listed above, inform your doctor promptly.  

Cautions 

Before using Anusol HC Suppository, inform your doctor and pharmacist if you have any known allergies, especially to hydrocortisone, zinc sulfate, or other medications. 

Anusol HC Suppository may contain inactive ingredients that can cause allergic reactions or other problems. Consult your pharmacist for further information. 

To ensure Anusol HC Suppository is safe for you, disclose to your physician your medical background, specifically regarding any history of: 

• Stomach/intestinal problems (ulcers, blockage, bleeding, infection, recent surgery) 
• Infections (tuberculosis, fungal infections) 
• Ocular conditions (cataracts, glaucoma, or herpes infection of the eye) 
• Heart problems (congestive heart failure, recent heart attack) 
• High blood pressure 
• Liver disease 
• Kidney disease 
• Thyroid problems (overactive or underactive thyroid disease) 
• Diabetes 
• Bone loss (osteoporosis) 
• Bleeding or blood clotting problems 
• Mental/mood conditions (psychosis, depression) 
• Low potassium blood level 

Many medications can potentially interact with Anuso HC Suppository, including aldesleukin, blood thinners like warfarin, and vaccines. To avoid such drug interactions, tell your physician and pharmacist about all the medications you are currently taking, such as prescription and non-prescription drugs, dietary supplements, and herbal products. 

To avoid the risk of bleeding, carefully read all your medication labels, as many contain pain relievers and fever reducers that can interact with Anusol HC Suppository. These may include aspirin, salicylates, and NSAIDs like ibuprofen and naproxen. However, if you have been advised by your doctor to take low-dose aspirin for heart attack or stroke prevention, continue taking it unless directed otherwise. Consult your pharmacist about safely using these products. 

The use of Anusol HC Suppository can weaken the immune system, making it harder for the body to fight infections and potentially prevent symptoms from developing. During use, avoid individuals with chicken pox or measles and contact your doctor right away if you suspect you have been exposed to someone with such a contagious disease. 

Inform your healthcare provider about the use of Anusol HC Suppository before any immunizations, vaccinations, or skin tests. Refrain from coming into contact with individuals who have recently received live vaccines, including the flu vaccine administered through the nose. 

The use of Anusol HC Suppository during pregnancy should be carefully considered, and only if the potential benefit outweighs the potential risk to the fetus. Pregnant patients should avoid extensive, high-dose, or long-term use of drugs in this class. 

Consult your doctor before breastfeeding while using Anusol HC Suppository, as it is unclear if hydrocortisone acetate or zinc sulfate transfer into breast milk.