Indications 

Wellbutrin, known as bupropion hydrochloride, is a type of antidepressant medication that is primarily used to treat major depressive disorder (MDD) or major depressive disorder with a seasonal pattern, previously known as seasonal affective disorder.  

The drug has been found to be effective in improving mood and feelings of well-being, potentially by restoring the balance of certain natural chemicals known as neurotransmitters in the brain. 

Uses and Dosage 

Prior to starting the use of bupropion, read the Patient Information Leaflet and Medication Guide provided by your pharmacist. In case of any queries, consult your doctor or pharmacist. 

Bupropion is to be taken orally, with or without food, three times a day as per the instructions of your physician. If you experience stomach upset, taking this medication with food may be considered.  

The dosage should be administered at intervals of at least 6 hours or as directed by your healthcare provider to minimize the risk of seizures. 

The manufacturer advises against crushing, cutting, or chewing the tablet before consumption. Nonetheless, many comparable medications (immediate-release tablets) can be crushed, cut, or chewed. Follow the guidance of your doctor regarding the administration of this medication. 

Do not alter the dosage or frequency of administration of the medication without consulting your physician. Exceeding the prescribed dose of bupropion may enhance the probability of experiencing seizures. 

The dosage is determined based on your medical condition and response to treatment. The dose may be gradually increased to limit side effects, such as insomnia, and minimize the risk of seizures. To prevent insomnia, avoid taking this medication too close to bedtime. Notify your doctor if insomnia becomes problematic. 

Side Effects 

Allergic Reactions

Seek emergency medical attention if you experience any of the following allergic reactions or severe skin reaction while taking Wellbutrin: 

• Hives 
• Itching 
• Fever 
• Swollen glands 
• Difficulty breathing 
• Swelling in your face or throat 
• Sore throat, burning eyes, skin pain, or red or purple skin rash with blistering and peeling 

Severe Side Effects

Report to your doctor immediately if you experience any new or worsening symptoms, such as: 

• Mood or behavior changes 
• Anxiety 
• Depression 
• Panic attacks 
• Trouble sleeping 
• Impulsive or agitated behavior 
• Hostility or aggression 
• Restlessness or hyperactivity (mentally or physically) 
• Thoughts of suicide or self-harm 

Contact your doctor right away if you experience any of the following: 

• Seizures (convulsions) 
• Confusion or unusual changes in mood or behavior 
• Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights 
• Fast or irregular heartbeats 
• A manic episode, such as racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, or having severe problems with sleep 

Common Side Effects  

• Dry mouth, sore throat, stuffy nose 
• Ringing in the ears 
• Blurred vision 
• Nausea, vomiting, stomach pain, loss of appetite, or constipation 
• Sleep problems (insomnia) 
• Tremors, sweating, or feeling anxious or nervous 
• Fast heartbeats 
• Confusion, agitation, or hostility 
• Rash 
• Weight loss 
• Increased urination 
• Headache, dizziness 
• Muscle or joint pain 

Caution 

Wellbutrin should not be taken if you have a history of seizures, an eating disorder, or if you have abruptly ceased using alcohol, seizure medications, or sedatives. 

If you are using Wellbutrin to treat depression, do not use Zyban to quit smoking. 

Wellbutrin should not be taken if you have used an MAO inhibitor within the past 14 days, as it could lead to a dangerous drug interaction. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. 

Seizures may occur when using Wellbutrin, particularly if you have specific medical conditions or when using certain medications. Inform your doctor of all your medical conditions and the drugs you are currently taking. 

Antidepressants like Wellbutrin may cause suicidal thoughts, especially in young people who have just started taking the medication. Your doctor will need to monitor your progress at regular visits while you are taking this medication.