Indications 

Aciphex is a medication indicated for the treatment and healing of Gastroesophageal Reflux Disease (GERD), Zollinger-Ellison Syndrome, and ulcers. The therapeutic use of Aciphex can effectively heal GERD, alleviate its symptoms, and promote ulcer healing within 4-8 weeks of treatment. It can be employed as a long-term therapy for symptomatic Zollinger-Ellison Syndrome. 

GERD is a type of acid reflux that results in the involuntary reflux of stomach acid into the esophagus, leading to esophageal damage and discomfort. The delayed-release tablet formulation of Aciphex enables the active ingredient rabeprazole to be absorbed in the intestines instead of the stomach, where GERD symptoms might potentially interfere with the drug’s efficacy. 

Uses and Dosage 

Before initiating rabeprazole therapy, carefully read the Medication Guide and Patient Information Leaflet provided by your pharmacist, and consult your doctor or pharmacist if you have any concerns. 

The delayed-release tablets should be swallowed whole with water and should not be crushed, chewed, or split, as this may affect the medication’s effectiveness. You may take this medication with or without food. 

The appropriate dose of rabeprazole varies based on individual factors such as the patient’s age, weight, medical condition, and the strength of the medication. Discuss your specific needs with your doctor to obtain a personalized prescription. 

To maximize the benefits of this medication, it should be taken regularly at the same time(s) each day. Even if your symptoms improve, complete the entire course of treatment as prescribed by your healthcare provider. 

Side Effects 

Allergic Reactions

Seek emergency medical help right away if you experience signs of an allergic reaction to AcipHex such as: 

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Contact your doctor immediately if you have any of the following symptoms: 

• Severe stomach pain or bloody/watery diarrhea 
• Sudden pain or difficulty moving hip, wrist, or back 
• Seizure (convulsions) 
• Kidney problems like:
  • Fever
  • Nausea
  • Joint pain
  • Rash
  • Loss of appetite
  • Blood in urine
  • Swelling
  • Rapid weight gain
  • Decreased urination 
• New or worsening symptoms of lupus such as:
  • Joint pain
  • Skin rash on cheeks or arms that worsens in sunlight 
• Low magnesium level causing:
  • Dizziness
  • Fast or irregular heart rate
  • Tremors or jerking muscle movements
  • Feeling jittery
  • Muscle cramps
  • Muscle spasms in hands and feet
  • Cough
  • Choking feeling 
• Signs of bleeding such as:
  • Headaches
  • Dizziness
  • Weakness
  • Pain or swelling
  • Bruising
  • Unusual bleeding
  • Red or pink urine
  • Heavy menstrual flow
  • Bloody or tarry stools
  • Coughing up blood or vomit that looks like coffee grounds
  • Any bleeding that will not stop 

Consult with your doctor about the risk of developing stomach growths called fundic gland polyps when taking rabeprazole long-term. 

If you use AcipHex for over 3 years, you may develop a vitamin B-12 deficiency. Discuss with your doctor on how to manage this condition. 

Common Side Effects 

• Infection 
• Pain 
• Sore throat 
• Headache 
• Nausea 
• Vomiting 
• Gas 
• Diarrhea 
• Constipation or stomach pain 

Caution 

Before taking rabeprazole, inform your healthcare provider or pharmacist of any allergies you have, including allergies to similar medications such as omeprazole and lansoprazole, or any other substances.  

This medication may contain inactive ingredients that can cause allergic reactions or other complications. Consult with your pharmacist to obtain additional details. 

Prior to using this medication, please discuss your medical history with your healthcare provider or pharmacist, particularly if you have a history of liver disease or lupus. 

Before undergoing any surgical procedures, inform your healthcare provider or dentist of all products you are currently using, including prescription medications, non-prescription medications, and herbal products. 

Long-term use of proton pump inhibitors such as rabeprazole may increase the risk of bone fractures, particularly in older adults, with higher doses and longer use. Speak to your healthcare provider or pharmacist to explore preventative measures, such as calcium (e.g., calcium citrate) and vitamin D supplements, to reduce the risk of bone loss and fractures. 

During pregnancy, this medication should only be used when necessary. Discuss the potential risks and benefits with your healthcare provider.