Indications 

Viibryd is indicated for the treatment of depression. This medication belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) and partial serotonin receptor agonists.  

It exerts its therapeutic effect by normalizing the balance of neurotransmitters, such as serotonin, in the brain. Viibryd is known to improve mood, appetite, sleep, energy levels, and restore the enjoyment of daily activities. 

Uses and Dosage 

Before taking vilazodone, read the Medication Guide provided by your pharmacist carefully. If you have any questions, seek clarification from your doctor or pharmacist.  

This medication should be taken by mouth with food as directed by your doctor, usually once daily. Your dosage will depend on your medical condition, response to treatment, and other medications you may be taking. Be sure to inform your doctor and pharmacist of all the products you use, including prescription drugs, nonprescription drugs, and herbal products. 

To minimize the risk of side effects, your doctor may start you at a low dose and gradually increase it. Follow your doctor’s instructions carefully. Do not take more or less medication or take it more frequently than prescribed, as doing so may increase your risk of side effects without improving your condition. 

For maximum benefit, use this medication regularly at the same time every day. If you suddenly stop using this medication, you may experience withdrawal symptoms such as mood swings, headache, tiredness, sleep changes, ringing in the ears, seizures, numbness/tingling, and “shock-like” feelings.  

To minimize the risk of withdrawal, your doctor may reduce your dose gradually, particularly if you have used vilazodone for an extended period or in high doses. If you experience withdrawal symptoms, contact your doctor or pharmacist immediately. 

Side Effects 

Allergic Reaction

Signs of an allergic reaction to Viibryd require immediate medical attention, including: 

• Skin rash or hives 
• Difficulty breathing 
• Swelling of face, lips, tongue, or throat 

Severe Side Effects

Report any new or worsening symptoms to your doctor, such as: 

• Mood or behavior changes 
• Anxiety 
• Panic attacks 
• Trouble sleeping 
• Impulsive behavior 
• Irritability 
• Agitation 
• Hostility 
• Aggressiveness 
• Restlessness 
• Hyperactivity (mentally or physically) 
• Increased depression 
• Thoughts about suicide or hurting oneself 

Call your doctor immediately if you experience: 

• Seizures (convulsions) 
• Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights 
• Easy bruising or unusual bleeding 
• Racing thoughts, unusual risk-taking behavior, decreased inhibitions, or feelings of extreme happiness or sadness 
• Low levels of sodium in the body, including headache, confusion, slurred speech, severe weakness, loss of coordination, or feeling unsteady 

Symptoms of serotonin syndrome require immediate medical attention, such as: 

• Agitation 
• Hallucinations 
• Fever 
• Sweating 
• Shivering 
• Fast heart rate 
• Muscle stiffness 
• Twitching 
• Loss of coordination 
• Nausea 
• Vomiting 
• Diarrhea 

Common Side Effects  

• Nausea 
• Vomiting 
• Diarrhea 
• Sleep problems (insomnia) 

Cautions 

Consider discussing your medical history with your healthcare provider before taking Viibryd, as certain medical conditions or factors may affect the safety and efficacy of this medication. These conditions include: 

• Bipolar disorder: Viibryd may induce hypomania or mania in individuals with bipolar disorder, leading to increased energy, racing thoughts, and restlessness. Prior to taking Viibryd, your doctor may screen you for bipolar disorder. 
• Seizures: Like other antidepressants, Viibryd may elevate the risk of seizures. Inform your doctor of your seizure history before initiating Viibryd treatment. 
• Glaucoma: If you have untreated angle-closure glaucoma, taking Viibryd may abruptly trigger glaucoma symptoms. Your healthcare provider may recommend alternative treatments for major depressive disorder. 
• Pregnancy: The impact of Viibryd on pregnancy is largely unknown. Further information is available in the “Viibryd and pregnancy” section. 
• Breastfeeding: The presence of Viibryd in breast milk and its effects on nursing infants remain unclear.