Indications 

Zyprexa is a pharmacological agent categorized as an atypical antipsychotic used in the treatment of psychotic conditions like bipolar disorder and schizophrenia. The active ingredient of this medication is Olanzapine, which belongs to the aforementioned drug class.  

Zyprexa exhibits efficacy in the management of manic episodes linked with bipolar disorder for short-term use. In addition, when administered in conjunction with fluoxetine, it may treat depressive episodes associated with bipolar I disorder.  

Zyprexa has demonstrated effectiveness in mitigating symptoms of schizophrenia, including but not limited to, hallucinations, agitations, delusions, and negative affect. 

Uses and Dosage 

Prior to initiating treatment with olanzapine, carefully review the Medication Guide furnished by the pharmacist, both at the outset of therapy and with each refill. Should any queries arise, seek the guidance of the prescribing physician or pharmacist. 

The medication is to be taken orally, either with or without food, in accordance with the instructions provided by the healthcare practitioner. Generally, the medication is taken once a day. 

The prescribed dosage of olanzapine is determined by the patient’s medical condition and their response to treatment. To minimize the likelihood of adverse effects, begin with a low dose, gradually increasing the dose as directed by the physician. Adhere to the doctor’s instructions carefully. 

To derive the maximum benefit from the medication, it should be taken regularly. Taking the medication at the same time each day can assist in remembering when to take it. Continue taking the medication even if feeling well. Discontinuing medication should only be done with the approval of the physician. 

Side Effects 

Allergic Reactions

If you experience signs of an allergic reaction to Zyprexa, seek emergency medical assistance immediately. These symptoms may include: 

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

In case of serious drug reaction, seek medical attention right away. These reactions may affect several parts of your body and include symptoms such as: 

• Skin rash 
• Fever 
• Swollen glands 
• Muscle aches 
• Severe weakness 
• Unusual bruising 
• Yellowing of your skin or eyes 

High doses or long-term use of olanzapine can lead to a serious movement disorder that might be irreversible. The following symptoms are more likely to occur with long-term use, especially in women or older adults: 

• Uncontrolled muscle movements in your face:
  • Chewing
  • Lip smacking
  • Frowning
  • Tongue movement
  • Blinking
  • Eye movement

Contact your doctor immediately if you experience any of the following symptoms: 

• Trouble speaking or swallowing 
• Swelling in your hands or feet 
• Confusion, unusual thoughts or behavior, hallucinations, or thoughts of hurting yourself 
• Low white blood cell counts:
  • Fever
  • Chills
  • Mouth sores
  • Skin sores
  • Sore throat
  • Cough
  • Trouble breathing
  • Feeling light-headed 
• Signs of dehydration:
  • Feeling very thirsty or hot
  • Being unable to urinate
  • Heavy sweating
  • Hot and dry skin 
• Liver problems:
  • Upper stomach pain
  • Itching
  • Loss of appetite
  • Dark urine
  • Clay-colored stools
  • Jaundice (yellowing of the skin or eyes) 
• High blood sugar:
  • Increased thirst
  • Increased urination
  • Hunger
  • Dry mouth
  • Fruity breath odor
  • Drowsiness
  • Dry skin
  • Blurred vision
  • Weight loss 
• Severe nervous system reaction:
  • Very stiff (rigid) muscles
  • High fever
  • Sweating
  • Confusion
  • Fast or uneven heartbeats
  • Tremors
  • Feeling like you might pass out 

Common Side Effects  

• Weight gain (more likely in teenagers) or increased appetite 
• Headache, dizziness, drowsiness, or feeling tired or restless 
• Problems with speech or memory 
• Tremors or shaking, numbness, or tingly feeling 
• Changes in personality 
• Dry mouth or increased salivation 
• Stomach pain or constipation 
• Pain in your arms or legs 

Caution 

Zyprexa, a medication used to treat certain mental health conditions, may cause impairment in thinking or reactions. Hence, be cautious while driving or performing tasks that require alertness. 

Alcohol consumption should be avoided while taking Zyprexa as it can increase the risk of adverse effects. 

Zyprexa is not approved for use in older adults with dementia-related psychosis due to the risk of death. 

The use of Zyprexa may lead to weight gain or high cholesterol and triglycerides levels, particularly in teenagers. Regular blood tests may be required, visit your healthcare provider frequently. 

Olanzapine, the active ingredient in Zyprexa, may increase blood sugar levels (hyperglycemia) in some individuals. Diabetic patients should monitor their blood sugar levels regularly.