Indications 

Zoladex is a synthetic hormone that mimics the function of a naturally occurring hormone responsible for regulating various bodily processes. By overstimulating the body’s production of specific hormones, goserelin temporarily suppresses their normal secretion. 

Zoladex implants are employed in the management of symptoms associated with prostate cancer in males. 

In females, the Zoladex implant is utilized for the treatment of breast cancer, endometriosis, and to prepare the uterine lining for endometrial ablation, a surgical procedure aimed at correcting abnormal uterine bleeding. 

Zoladex is occasionally administered in conjunction with another cancer medication called flutamide to optimize therapeutic outcomes. 

Uses and Dosage 

Prior to initiating the use of goserelin, carefully review the Patient Information Leaflet, if provided, which can be obtained from your pharmacist. Consult your doctor or pharmacist if you have any inquiries or concerns. 

Goserelin is an implant designed to gradually release hormones into the body. Administration of the implant is performed by a healthcare professional through subcutaneous injection in the lower abdomen below the navel. Over a period of weeks or months, the implant will be fully absorbed by the body. 

Ensure that you receive this medication as prescribed by your doctor. The 3.6-milligram syringe is typically administered every 4 weeks. Adhere to the prescribed dosing schedule meticulously in order to maximize the therapeutic benefits.  

To aid in remembering the next dose, it may be helpful to mark your calendar accordingly. Do not discontinue this medication without the approval of your doctor. 

The dosage of goserelin is determined based on your medical condition and response to treatment. 

In women, regular menstrual periods should cease when goserelin is administered regularly. If menstrual periods persist after 2 months of treatment with goserelin. 

Side Effects 

Allergic Reaction

Please seek immediate medical assistance if you experience any of the following allergic reaction symptoms while using Zoladex: 

• Hives 
• Difficulty breathing 
• Swelling of the face, lips, tongue, or throat 

Severe Side Effects

During the initial stages of Zoladex treatment, If you notice any of the following symptoms, promptly inform your doctor: 

• Back pain 
• Painful or difficult urination 
• Loss of movement in any part of your body 
• Loss of bowel or bladder control 

Contact your doctor immediately if you encounter any of the following conditions: 

• Pain, bruising, swelling, redness, oozing, or bleeding at the site of injection 
• Dizziness, difficulty breathing, or a feeling of lightheadedness that may lead to fainting 
• High blood sugar levels, characterized by increased thirst, frequent urination, dry mouth, or a fruity breath odor 
• Elevated calcium levels, which may cause confusion, fatigue, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, or weight loss 
• Symptoms of a heart attack, including chest pain or pressure, pain that spreads to the jaw or shoulder, nausea, or sweating 
• Indications of a blood clot, such as sudden numbness or weakness on one side of the body, chest pain, vision or speech problems, or pain or swelling in one leg 

Common Side Effects

Common side effects of Zoladex may include: 

• Hot flashes and excessive sweating 
• Painful urination 
• Mood changes and altered interest in sexual activities 
• Changes in sexual function, leading to fewer erections than usual 
• Headaches 
• Swelling in the hands or feet 
• Vaginal dryness, itching, or discharge 
• Alterations in breast size 
• Acne, mild skin rash, or itching 

Caution 

The use of Zoladex during pregnancy should be avoided, as it has the potential to harm the unborn baby or cause birth defects, unless specifically prescribed for advanced breast cancer. Employ effective non-hormonal (barrier) birth control methods throughout the course of treatment and for a minimum of 12 weeks after treatment cessation. In the event of pregnancy occurring during treatment, immediate notification of your doctor is crucial. Furthermore, breastfeeding should not be practiced while using Zoladex. 

Zoladex should not be administered to individuals with a known allergy to goserelin or similar hormone medications, such as leuprolide (Lupron, Eligard, Viadur), nafarelin (Synarel), or ganirelix (Antagon). 

Prior to receiving Zoladex, inform your doctor if you have osteoporosis, diabetes, urination difficulties, spinal conditions, a history of heart attack or stroke, risk factors for coronary artery disease (such as high blood pressure, high cholesterol, smoking, or obesity), or if you have experienced uninvestigated abnormal bleeding. 

Zoladex has the potential to decrease bone mineral density, thereby increasing the risk of osteoporosis development. This risk may be heightened by smoking, frequent alcohol consumption, a family history of osteoporosis, or the use of specific medications like seizure medications or steroids. discuss your individual risk of bone loss with your doctor.